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Editorial
. 2019 Jan;11(1):21-28.
doi: 10.21037/jtd.2018.11.74.

Improving clinical outcomes in sepsis and multiple organ dysfunction through precision medicine

Sanjay Mehta  1   2   3 , Sean E Gill  1   2   3   4
Affiliations
Editorial

Improving clinical outcomes in sepsis and multiple organ dysfunction through precision medicine

Sanjay Mehta et al. J Thorac Dis. 2019 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Sepsis is defined as a dysregulated host response to infection leading to life-threatening single or multiple organ dysfunction (MOD). The pathophysiology of septic organ dysfunction is not established, especially the potential key role of microvascular endothelial cell (EC) dysfunction. Treatment of infection and excellent intensive care unit (ICU) supportive care (√) have improved sepsis mortality, but clinical outcomes remain poor because of a lack of any pathobiology-based targeted treatment options for the key pathophysiologic features (×), particularly microvascular EC dysfunction and resulting organ dysfunction, especially MOD. ARDS, acute respiratory distress syndrome; Macs, macrophages; PMN, polymorphonuclear leukocytes; RCTs, randomized controlled trials.
See this image and copyright information in PMC

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