Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan;11(1):329-334.
doi: 10.21037/jtd.2018.10.116.

The value of using radial endobronchial ultrasound to guide transbronchial lung cryobiopsy

Ankit Gupta  1 , Houssein Youness  2 , Samjot Singh Dhillon  3 , Kassem Harris  4
Affiliations
Review

The value of using radial endobronchial ultrasound to guide transbronchial lung cryobiopsy

Ankit Gupta et al. J Thorac Dis. 2019 Jan.

Abstract

Conventional transbronchial biopsies have a low diagnostic yield for interstitial lung disease (ILD) and peripheral lung nodules due to crush artifact and smaller tissue samples. Transbronchial lung cryobiopsies (TBLC) circumvent these drawbacks but are associated with higher incidence of complications including life threatening airway bleeding and pneumothoraces. Radial probe endobronchial ultrasound (RP-EBUS) can be used during the TBLC for assessing the biopsy site prior to the cryobiopsy to avoid vasculature and to decrease the risk of complications. There is no standardized protocol for this technique and the available literature mostly consists of single center case reports/series. The aim of this review is to investigate the existing literature for RP-EBUS assisted TBLC for diagnosing both ILD and peripheral lung nodules. We will describe the techniques used and compare the diagnostic yield and complication rates with other modalities.

Keywords: Cryobiopsy; endobronchial ultrasound (EBUS); interstitial lung disease (ILD); nodule.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: the authors have no conflicts of interest to declare.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Rodgers BM, Rosenfeld M, Talbert JL. Endobronchial cryotherapy in the treatment of tracheal strictures. J Pediatr Surg 1977;12:443-9. 10.1016/0022-3468(77)90023-9 - DOI - PubMed
    1. Marasso A, Gallo E, Massaglia GM, et al. Cryosurgery in bronchoscopic treatment of tracheobronchial stenosis. Indications, limits, personal experience. Chest 1993;103:472-4. 10.1378/chest.103.2.472 - DOI - PubMed
    1. Mathur PN, Wolf KM, Busk MF, et al. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest 1996;110:718-23. 10.1378/chest.110.3.718 - DOI - PubMed
    1. DiBardino DM, Lanfranco AR, Haas AR. Bronchoscopic Cryotherapy. Clinical Applications of the Cryoprobe, Cryospray, and Cryoadhesion. Ann Am Thorac Soc 2016;13:1405-15. 10.1513/AnnalsATS.201601-062FR - DOI - PubMed
    1. Franke KJ, Theegarten D, Hann von Weyhern C, et al. Prospective controlled animal study on biopsy sampling with new flexible cryoprobes versus forceps: evaluation of biopsy size, histological quality and bleeding risk. Respiration 2010;80:127-32. 10.1159/000287251 - DOI - PubMed