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. 2019 Feb;23(1):34-40.
doi: 10.14701/ahbps.2019.23.1.34. Epub 2019 Feb 28.

Gangrenous cholecystitis in male patients: A study of prevalence and predictive risk factors

Carlos Augusto Gomes  1 , Cleber Soares  1 , Salomone Di Saverio  2 , Massimo Sartelli  3 , Poliana Graciele de Souza Silva  4 , Agnes Silva Orlandi  4 , Thais Lacerda Heringer  4 , Felipe Couto Gomes  5 , Fausto Catena  6
Affiliations

Gangrenous cholecystitis in male patients: A study of prevalence and predictive risk factors

Carlos Augusto Gomes et al. Ann Hepatobiliary Pancreat Surg. 2019 Feb.

Abstract

Backgrounds/aims: The prevalence and risk factors of gangrenous cholecystitis in male are unknown.

Objective: To verify the prevalence and risk factors of gangrenous cholecystitis in males.

Methods: This cross-sectional study includes 95 patients (59.5±17.1 years), with clinical and histopathological diagnosis, operated laparoscopically on 2012-2016. Eligibility was decided based on the variables of age; tachycardia (>100 bpm); leukocytosis (>10,000/mm3); Murphy's sign; gallbladder wall thickness (>4 mm); biochemical tests, morbidities (diabetes, alcoholism, smoking) and mortality. Multivariate regression, the chi-squared and Prevalent Chances Ratio (PCR) were used to define a few parameters.

Results: The prevalence of gangrenous cholecystitis in men older than 50 years was 29.3%. The risk factors for the disease were as follows: diabetes mellitus (p=0.006, RCP=4.191), leukocytosis (p=0.003), gallbladder thickness greater than 4 mm (p=0.035, RCP=3.818), which increased mortality [(p=0.04) (RCP=8.001)]. Murphy's sign showed a negative association (p=0.002, RCP=0.204). Values close to significance were observed in relation to gamma glutamyl transferase (p=0.083, RCP=3.125) and hospital stay (p=0.061, RCP=2.765).

Conclusions: Male gender, and age older than 50 years, were correlated with a high prevalence of necrosis, higher than that reported in females. The risk factors for developing necrosis are the same as those described for female patients.

Keywords: Abdominal infections; Abdominal surgery; Cholecystectomy; Complication; Laparoscopic surgery.

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References

    1. Hunt DR, Chu FC. Gangrenous cholecystitis in the laparoscopic era. Aust N Z J Surg. 2000;70:428–430. - PubMed
    1. Ganapathi AM, Speicher PJ, Englum BR, Perez A, Tyler DS, Zani S. Gangrenous cholecystitis: a contemporary review. J Surg Res. 2015;197:18–24. - PubMed
    1. Di Saverio S. Emergency laparoscopy: a new emerging discipline for treating abdominal emergencies attempting to minimize costs and invasiveness and maximize outcomes and patients' comfort. J Trauma Acute Care Surg. 2014;77:338–350. - PubMed
    1. Terho PM, Leppäniemi AK, Mentula PJ. Laparoscopic cholecystectomy for acute calculous cholecystitis: a retrospective study assessing risk factors for conversion and complications. World J Emerg Surg. 2016;11:54. - PMC - PubMed
    1. Yokoe M, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Gomi H, et al. ; Tokyo Guidelines Revision Committee. TG13 diagnostic criteria and severity grading of acute cholecystitis (with videos) J Hepatobiliary Pancreat Sci. 2013;20:35–46. - PubMed

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