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. 2019 Oct;17(10):2106-2114.
doi: 10.11124/JBISRIR-2017-003847.

Impact of lifestyle modification on absolute cardiovascular disease risk: a systematic review protocol

Jacob K Kariuki  1 , Cortes I Yamnia  2 , Christopher C Imes  1 , Patricia M Weiss  3 , Sandra J Engberg  1
Affiliations

Impact of lifestyle modification on absolute cardiovascular disease risk: a systematic review protocol

Jacob K Kariuki et al. JBI Database System Rev Implement Rep. 2019 Oct.

Abstract

Objective: The objective of this review is to synthesize the available evidence on the effectiveness of lifestyle-based interventions for reducing absolute cardiovascular disease (CVD).

Introduction: Cardiovascular disease prevention guidelines recommend tailoring the choice and intensity of preventive interventions based on absolute CVD risk score. Several studies employing lifestyle-based interventions to mitigate CVD risk have reported heterogeneous outcomes, necessitating a systematic review to provide an exhaustive summary of current evidence.

Inclusion criteria: Eligible studies will include individuals at high-risk of CVD who are at least 18 years of age, with no history of CVD at baseline, regardless of sex, ethnicity and socio-economic status. Studies that compare lifestyle-based intervention to no intervention or usual care will be included. The outcome of interest is change in absolute CVD risk from baseline to post-intervention. Experimental and quasi-experimental study designs will be included.

Methods: Searches will be conducted in PubMed, EMBASE and CINAHL from the inception of each database. The search for gray literature will include ProQuest Dissertations and Theses Global, Grey Literature Report, Web of Science, BIOSIS Previews and the Proceedings database. Selected studies will be critically appraised by two independent reviewers at the study level for methodological quality. Extracted data will include details about the interventions, populations, study methods and outcomes of significance to the review question and objectives. Where possible, papers will be pooled in statistical meta-analysis. Effect sizes will be expressed as either odds ratios or standardized mean differences, and their 95% confidence intervals will be calculated for analysis.

Systematic review registration number: PROSPERO CRD42017073543.

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Conflict of interest statement

The authors declare no conflict of interest.

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