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. 2019 Jun;38(6):668-673.
doi: 10.1097/ICO.0000000000001919.

Outcomes of Cyanoacrylate Tissue Adhesive Application in Corneal Thinning and Perforation

Jia Yin  1 , Rohan Bir Singh, Rani Al Karmi, Ann Yung, Man Yu, Reza Dana
Affiliations

Outcomes of Cyanoacrylate Tissue Adhesive Application in Corneal Thinning and Perforation

Jia Yin et al. Cornea. 2019 Jun.

Abstract

Purpose: To report the outcomes of cyanoacrylate tissue adhesive (CTA) application in corneal thinning and perforation.

Methods: A retrospective interventional case series of 137 patients receiving CTA for corneal thinning and perforation in 140 eyes between 2001 and 2018 at a single center was reviewed. Success rate and factors associated with glue failure were analyzed.

Results: Median age of the cohort was 63 years and 69 (50%) were women. One hundred fifteen patients (84%) had at least 1 systemic condition, 46 (34%) had autoimmune diseases. Eighty-nine eyes (64%) presented with perforation and 51 (36%) with thinning. The perforation/thinning was central/paracentral in 82 eyes (59%) and peripheral in 57 eyes (41%). Median size of perforation was 3.1 mm. Causes of perforation and thinning were microbial infection in 75 (55%), sterile melt in 49 (35%), laceration in 10, and keratoprosthesis melt in 8 eyes. Median glue retention was 58 days. Success rate of glue application (defined as intact globe without surgical intervention) was 72%, 61%, and 46% at 10, 30, and 90 days after glue application, respectively. Larger size of perforation/thinning, perforation (vs. thinning), and single glue application (vs. multiple) were correlated with higher failure rate. Systemic conditions, use of topical corticosteroid, etiologies, and location of perforation/thinning were not significantly correlated with glue failure.

Conclusions: CTA application was moderately effective in stabilizing corneal perforation and thinning in the very short-term. Multiple applications are often required. Maintenance of globe integrity after glue application decreases with time and the need for surgical intervention remains high.

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Figures

Figure 1.
Figure 1.
Outcomes of CTA application. A. Kaplan-Meier curve of single CTA application success. Success is defined as an intact globe without additional intervention. B. Kaplan-Meier curve of Multiple CTA application success. Success of multiple CTA application is defined as an intact globe without surgical intervention. CTA: cyanoacrylate tissue adhesive
See this image and copyright information in PMC

Comment in

  • Anterior lens capsule: Biological drape.
    Beniwal A, Bafna RK, Sharma N. Beniwal A, et al. Indian J Ophthalmol. 2023 Mar;71(3):1012-1015. doi: 10.4103/IJO.IJO_2629_22. Indian J Ophthalmol. 2023. PMID: 36872729 Free PMC article.

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