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Review
. 2018 May;36(3-04):183-194.
doi: 10.1055/s-0038-1675778. Epub 2019 Mar 13.

Child Health: Is It Really Assisted Reproductive Technology that We Need to Be Concerned About?

Edwina H Yeung, Keewan Kim, Alexandra Purdue-Smithe, Griffith Bell, Jessica Zolton, Akhgar Ghassabian  1   2   3 , Yassaman Vafai, Sonia L Robinson, Sunni L Mumford
Affiliations
Review

Child Health: Is It Really Assisted Reproductive Technology that We Need to Be Concerned About?

Edwina H Yeung et al. Semin Reprod Med. 2018 May.

Abstract

Concerns remain about the health of children conceived by infertility treatment. Studies to date have predominantly not identified substantial long-term health effects after accounting for plurality, which is reassuring given the increasing numbers of children conceived by infertility treatment worldwide. However, as technological advances in treatment arise, ongoing studies remain critical for monitoring health effects. To study whether the techniques used in infertility treatment cause health differences, however, remains challenging due to identification of an appropriate comparison group, heterogeneous treatment, and confounding by the underlying causes of infertility. In fact, the factors that are associated with underlying infertility, including parental obesity and other specific male and female factors, may be important independent factors to consider. This review will summarize key methodological considerations in studying children conceived by infertility treatment including the evidence of associations between underlying infertility factors and child health.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1.
Figure 1.
Conceptual Diagram for Examining the Association between Use of Assisted Reproductive Technologies (ART) and Offspring Neurodevelopment.
See this image and copyright information in PMC

References

    1. Calhaz-Jorge C, De Geyter C, Kupka MS, et al. Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE. Human Reproduction 2017;32(10):1957–1973 - PubMed
    1. Sunderam S, Kissin DM, Crawford SB, et al. Assisted Reproductive Technology Surveillance - United States, 2015. MMWR: Surveillance Summaries 2018;67(3):1–28 - PMC - PubMed
    1. Kushnir VA, Barad DH, Albertini DF, Darmon SK, Gleicher N. Systematic review of worldwide trends in assisted reproductive technology 2004–2013. Reproductive Biology and Endocrinology 2017;15(1):6. - PMC - PubMed
    1. Schieve LA, Devine O, Boyle CA, Petrini JR, Warner L. Estimation of the contribution of non-assisted reproductive technology ovulation stimulation fertility treatments to US singleton and multiple births. American Journal of Epidemiology 2009;170(11):1396–1407 - PubMed
    1. Zore T, Wang ET. Perinatal and Childhood Outcomes Associated with Infertility. Seminars in Reproductive Medicine 2017;35(3):304–310 - PubMed

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