Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Mar 3;38(2):164-171.
doi: 10.2478/jomb-2018-0021. eCollection 2019 Apr.

Relationship Between Hematological Parameters and Glycemic Control in Type 2 Diabetes Mellitus Patients

Dragana Milosevic  1   2 , Violeta Lukic Panin  2
Affiliations

Relationship Between Hematological Parameters and Glycemic Control in Type 2 Diabetes Mellitus Patients

Dragana Milosevic et al. J Med Biochem. .

Abstract
in English, Serbian

Background: Diabetes mellitus (DM) with its micro- and macrocomplications is the leading global epidemic of the 21st century. The aim of the research is to determine possible changes in the complete blood count (CBC) parameters depending on glycemic controlin patients with Type 2 diabetes mellitus (T2DM).

Methods: The study included a total of 178 patients with T2DM, both gender over the age of 40 years, from the Health Care Center »Dr Milorad Mika Pavlović« Indjija, Serbia. To notice the possible correlation between the CBC parameters and glucose control in T2DM, the subjects were divided in two groups with HbA1c ≤ 7% and with HbA1c>7%. We analysed CBC parameters, parameters of glycoregulation, lipid status using standard biochemical methods, performed anthropometric measurements and collected patients data by questionnaire and electronic patient card.

Results: There was statistical difference between HbA1c groups for PMDW (p=0.045), HDL (p=0.0067). Using univariate linear regression it is shown that PCT was correlated with WBC (p=0.0005), neutrophils (p=0.046), monocytes (p=0.003); MPM was associated with MPV (p=0.0005); MPC (p=0.0005), PDW (P=0.0005), GLU0 (p=0.034), HDL-C (p=0.005); PMDW was correlated with HbA1c% (p=0.049), GLU0 (p=0.013), HDL-C (p=0.001), BW (p=0.043) in all patients.

Conclusions: Based on our study results it may be concluded that some of the parameters of CBC could be useful tool in following glycemic control of diabetics.

Uvod: Diabetes mellitus (DM) sa mikro i makrokomplikacijama je vodeća globalna epidemija 21. veka. Cilj istraživanja je da se utvrde eventualne promene parametara kompletne krvne slike (KKS) u zavisnosti od glikoregulacije kod pacijenata sa šećernom bolesti tip 2 (DM tip 2).

Metode: Istraživanjem je obuhvaćeno ukupno 178 pacijenata sa DM tip 2, oba pola, starijih od 40 godina, iz Doma zdravlja »Dr Milorad Mika Pavlović«; Inđija, Srbija. Da bi se utvrdila moguća povezanost između parametara KKS i glikoregulacije u T2DM, ispitanici su podeljeni u dve grupe, sa HbA1c ≤ 7% i sa vrednostima HbA1c>7%. Analizirani su parametri KKS, parametri glikoregulacije, lipidni status korišćenjem standardnih biohemijskih postupaka, a vršena su i antropometrijska merenja. Podaci od pacijenata prikupljeni su putem upitnika i elektronskog kartona pacijenta.

Rezultati: Utvrđena je statistički značajna razlika između grupa za PMDW (p=0,045), HDL-C (p=0,0067). Kod svih pacijenata (univarijabilna linearna regresija) rezultati su pokazali daje PCT povezan sa leukocitima (p=0,0005), neutrofilima (p=0,046), monocitima (p=0,003); MPM je u korelaciji sa MPV (p=0,0005); MPC (p=0,0005), PDW (p=0,0005), GLU0 (p=0,034), HDL-C (p=0,005); PMDW je u korelaciji sa HbA1c% (p=0,049), GLU0 (p=0,013), HDL-C (p=0,001), telesnom masom (p=0,043).

Zaključak: Na osnovu dobijenih rezultata našeg istraživanja može se zaključiti da postoji povezanost između pojedinih hematoloških parametara i glikoregulacije kod pacijenata sa dijabetesom.

Keywords: CBC parameters; HbA1c; T2DM; platelets.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest Conflict of interest statement: The authors state that they have no conflicts of interest regarding the publication of this article.

References

    1. World Health Organization (WHO) Diabetes research. http://www.who.int/diabetes/en/ Available at. (Last accessed on May 10, 2017)
    1. Incidencija i mortalitet od dijabetesa u Srbiji 2016. Institut za javno zdravlje Srbije »Dr Milan Jovanovi Batut«. 2016 http://www.batut.org.rs/index.php?Content=187 Available at. (Last accessed on May 5, 2017)
    1. Ziaee A, Ghorbani A, Kalbasi S, Hejrati A, Moradi S.. Association of hematological indices with prediabetes: A cross-sectional study. Electronic Physician. 2017;9(9):5206–11. - PMC - PubMed
    1. Drzewoski J, Kasznicki J, Trojanowski Z.. The role of « in the natural history of diabetes mellitus. Pol Arch Med Wewn. 2009;119(7–8):493–500. - PubMed
    1. Ting DS, Cheung GC, Wong TY.. Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review. Clin Exp Ophthalmol. 2016;44(4):260–77. - PubMed

LinkOut - more resources