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. 2019 Mar;17(3):3392-3398.
doi: 10.3892/ol.2019.9964. Epub 2019 Jan 23.

Effects of dezocine and sufentanyl for postoperative analgesia on activity of NK, CD4+ and CD8+ cells in patients with breast cancer

Fei Wang  1 , Xue Zhang  1 , Huihui Wang  1 , Yi Liu  1
Affiliations

Effects of dezocine and sufentanyl for postoperative analgesia on activity of NK, CD4+ and CD8+ cells in patients with breast cancer

Fei Wang et al. Oncol Lett. 2019 Mar.

Abstract

The effects of dezocine and sufentanyl on the activity of natural killer (NK), CD4+ and CD8+ cells in patients with breast cancer undergoing postoperative analgesia after radical mastectomy were compared. The clinical data of 76 female patients undergoing radical mastectomy in the Fudan University Shanghai Cancer Center from January 2015 to October 2017 were analyzed retrospectively. Forty-two patients treated with dezocine were group D and 34 patients with sufentanyl were group S. Visual analogue scale (VAS) was used to evaluate the analgesic effect at 3, 12, 24, 48 h after surgery. There was no significant difference in VAS score, NK cells, CD4+ cells, and CD8+ cell vitality at 3 h postoperatively between the two groups (P>0.05), and VAS score at 12, 24 and 48 h postoperatively in the S group was significantly lower than that in group D (P<0.05). The activity of NK cells and CD4+ cells at 3, 12, 24 and 48 h after surgery in group D was significantly higher than that in group S, and the difference was statistically significant (P<0.05). The activity of CD8+ cells at 3, 12, 24 and 48 h after surgery in group D was significantly lower than that in group S, and the difference was statistically significant (P<0.05). The analgesic effect of dezocine was slightly worse than that of sufentanyl, but it was more beneficial to the recovery of early postoperative immune function.

Keywords: CD4+; CD8+; NK cells; breast cancer; dezocine; postoperative analgesia; sufentanyl.

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Figures

Figure 1.
Figure 1.
VAS score in patients of the two groups. There was no significant difference in VAS score between the groups at 3 h after surgery (P>0.05), and the VAS score in group S was significantly lower than that in group D at 12, 24 and 48 h after surgery, and the difference was statistically significant (P<0.05). There was statistical difference between groups D and S at each time-point after surgery (P<0.001). There was no significant difference in VAS score between 12 h, 24 h after surgery and 3 h after surgery in group D (P>0.05), and VAS score at 48 h after surgery was significantly lower than that at 3, 12 and 24 h after surgery, and the difference was statistically significant (P<0.05). There was no significant difference in VAS score between 12 and 3 h after surgery in group S (P>0.05), and VAS score at 24 and 48 h after surgery was significantly lower than that at 3 and 12 h after surgery, and 48 h after surgery was significantly lower than that 24 h after surgery, and the difference was statistically significant (P<0.05). *P<0.05 compared with 3 h after surgery; #P<0.05 compared with 12 h after surgery; &P<0.05 compared with 24 h after surgery.
Figure 2.
Figure 2.
Comparison of NK cell activity between the two groups. Flow cytometry showed that the activity of NK cells in group D was significantly higher than that in group S at 3, 12, 24 and 48 h after surgery, and the difference was statistically significant (P<0.05). The activity of NK cells in group D at 3, 12 and 24 h after surgery was significantly lower than that before surgery, and the activity at 12, 24, 48 h after surgery was significantly higher than that at 3 h after surgery, and 24 h and 48 h after surgery was significantly higher than that at 12 h after surgery, and 48 h after surgery was significantly higher than that at 24 h after surgery, and the difference was statistically significant (P<0.05). The activity of NK cells in group S at 3, 12, 24 and 48 h after surgery was significantly lower than that before surgery, and the activity at 12, 24, 48 h after surgery was significantly higher than that at 3 h after surgery, and 24 h, 48 h after surgery was significantly higher than that at 12 h after surgery, and 48 h after surgery was significantly higher than that at 24 h after surgery, and the difference was statistically significant (P<0.05). *P<0.05 compared with before surgery; #P<0.05 compared with 3 h after surgery; &P<0.05 compared with 12 h after surgery; @P<0.05 compared with 24 h after surgery.
Figure 3.
Figure 3.
Comparison of CD4+ cell activity between the two groups. Flow cytometry showed that the activity of CD4+ cells in group D was significantly higher than that in group S at 3, 12, 24 and 48 h after surgery, and the difference was statistically significant (P<0.05). The activity of CD4+ cells at 3, 12, 24 h after surgery was significantly lower than that before surgery in group D, and 12, 24, 48 h after surgery was significantly higher than that 3 h after surgery, and 24 h, 48 h after surgery was significantly higher than that 12 h after surgery, and the difference was statistically significant (P<0.05). The activity of CD4+ cells at 3, 12, 24 h after surgery was significantly lower than that before surgery in group S, and 12, 24, 48 h after surgery was significantly higher than that 3 h after surgery, and 24, 48 h after surgery was significantly higher than that 12 h after surgery, and the difference was statistically significant (P<0.05). *P<0.05 compared with before surgery; #P<0.05 compared with 3 h after surgery; &P<0.05 compared with 12 h after surgery.
Figure 4.
Figure 4.
Comparison of CD8+ cell activity between the two groups. Flow cytometry showed that the activity of CD8+ cells in group D was significantly lower than that in group S at 3, 12, 24 and 48 h after surgery, and the difference was statistically significant (P<0.05). The activity of CD8+ cells at 24 and 48 h after surgery was significantly lower than that before surgery and 3 h after surgery in group D, and the activity at 48 h after surgery was significantly lower than that at 12 and 24 h after surgery, and the difference was statistically significant (P<0.05). The activity of CD8+ cells at 3 and 12 h after surgery was significantly lower than that before surgery in group S, and the activity at 24 and 48 h after surgery was significantly lower than that at 3 and 12 h after surgery, and the difference was statistically significant (P<0.05). *P<0.05 compared with before surgery; #P<0.05 compared with 3 h after surgery; &P<0.05 compared with 12 h after surgery; @P<0.05 compared with 24 h after surgery.
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