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Review
. 2019 Apr;70(4):260-264.
doi: 10.1007/s00105-019-4378-8.

[Dermatitis herpetiformis]

[Article in German]
H A Juratli  1 , A Görög  2 , M Sárdy  2
Affiliations
Review

[Dermatitis herpetiformis]

[Article in German]
H A Juratli et al. Hautarzt. 2019 Apr.

Abstract

Dermatitis herpetiformis (DH) is a genetically determined, gluten sensitive autoimmune bullous dermatosis related to celiac disease in which granular, insoluble aggregates in the papillary dermis of epidermal transglutaminase (TG3), immunoglobulin A (IgA), and fibrinogen are present. Detection of the dermal IgA-TG3 immune complex is the gold standard of diagnosis. DH develops in a subpopulation of patients with gluten sensitive enteropathy, characterized by itching, erythematous, excoriated papules showing characteristic distribution over the knees, elbows and buttocks; vesicles are rarely seen. The primary therapy of DH is a strict, lifelong gluten-free diet, and it may be necessary to temporarily give dapsone in case of severe symptoms.

Keywords: Autoimmune diseases; Coeliac disease; Gluten sensitive enteropathy; Immune complex; Transglutaminase.

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References

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