Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2019 Jan:147:e91.
doi: 10.1017/S0950268819000037.

Invasive pneumococcal disease in hospitalised children from Lima, Peru before and after introduction of the 7-valent conjugated vaccine

A Luna-Muschi  1 , F Castillo-Tokumori  1 , M P Deza  1 , E H Mercado  1 , M Egoavil  1 , K Sedano  1 , M E Castillo  1 , I Reyes  2 , E Chaparro  1 , R Hernández  1 , W Silva  2 , O Del Aguila  2 , F Campos  2 , A Saenz  2 , T J Ochoa  1
Affiliations
Multicenter Study

Invasive pneumococcal disease in hospitalised children from Lima, Peru before and after introduction of the 7-valent conjugated vaccine

A Luna-Muschi et al. Epidemiol Infect. 2019 Jan.

Abstract

The objective of this study was to determine the serotype distribution and antibiotic resistance of invasive pneumococcal disease (IPD) strains in children from Lima, Peru, before and after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7), which was introduced in the national immunisation program on 2009. We conducted a prospective, multicentre, passive surveillance IPD study during 2006-2008 and 2009-2011, before and right after the introduction of PCV7 in Peru. The study was performed in 11 hospitals and five private laboratories in Lima, Peru, in patients <18 years old, with sterile site cultures yielding Streptococcus pneumoniae. In total 159 S. pneumoniae isolates were recovered. There was a decrease in the incidence of IPD in children <2 years old after the introduction of PCV7 (18.4/100 000 vs. 5.1/100 000, P = 0.004). Meningitis cases decreased significantly in the second period (P = 0.036) as well as the overall case fatality rate (P = 0.025), including a decreased case fatality rate of pneumonia (16.3% to 0%, P = 0.04). PCV7 serotypes showed a downward trend. Vaccine-preventable serotypes caused 78.9% of IPD cases, mainly 14, 6B, 5, 19F and 23F. A non-significant increase in erythromycin resistance was reported. Our findings suggest that the introduction of PCV7 led to a significant decrease of IPD in children under 2 years old and in the overall case fatality rate.

Keywords: PCV7; Peru; Streptococcus pneumoniae; pneumococcal conjugated vaccine; pneumococcal infections.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Fig. 1.
Fig. 1.
Cumulative cases of invasive pneumococcal disease (IPD) according to study period. Black line: 2006–2008; grey line 2009–2011.
See this image and copyright information in PMC

References

    1. O'Brien KL et al. (2009) Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. The Lancet 374, 893–902. - PubMed
    1. Jones RN et al. (2013) Susceptibility rates in Latin American nations: report from a regional resistance surveillance program (2011). The Brazilian Journal of Infectious Diseases 17, 672–681. - PMC - PubMed
    1. Whitney CG et al. (2003) Decline in invasive pneumococcal disease after the introduction of protein–polysaccharide conjugate vaccine. New England Journal of Medicine 348, 1737–1746. - PubMed
    1. Hicks LA et al. (2007) Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998–2004. The Journal of Infectious Diseases 196, 1346–1354. - PubMed
    1. Ochoa TJ et al. (2010) Invasive pneumococcal diseases among hospitalized children in Lima, Peru. Revista Panamericana de Salud Pública 28, 121–127. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources