Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2019 Jan:147:e83.
doi: 10.1017/S0950268818003400.

The prevalence, temporal trends, and geographical distribution of HIV-1 subtypes among men who have sex with men in China: A systematic review and meta-analysis

Yueqi Yin  1 , Yuxiang Liu  1 , Jing Zhu  1 , Xiang Hong  1 , Rui Yuan  2 , Gengfeng Fu  3 , Ying Zhou  3 , Bei Wang  1
Affiliations
Meta-Analysis

The prevalence, temporal trends, and geographical distribution of HIV-1 subtypes among men who have sex with men in China: A systematic review and meta-analysis

Yueqi Yin et al. Epidemiol Infect. 2019 Jan.

Abstract

The aim of this meta-analysis was to provide a comprehensive overview of human immunodeficiency virus (HIV)-1 subtypes and to investigate temporal and geographical trends of the HIV-1 epidemic among men who have sex with men (MSM) in China. Chinese and English articles published between January 2007 and December 2017 were systematically searched. Pooled HIV-1 prevalence was calculated, and its stability was analysed using sensitivity analysis. Subgroups were based on study time period, sampling area and prevalence. Publication bias was measured using Funnel plot and Egger's test. A total of 68 independent studies that included HIV-1 molecular investigations were eligible for meta-analysis. Circulating recombinant form (CRF) 01_AE (57.36%, 95% confidence interval (CI) 53.76-60.92) was confirmed as the most prevalent HIV-1 subtype among MSM in China. Subgroup analysis for time period found that CRF01_AE steadily increased prior to 2012 but decreased during 2012-2016. Further whereas CRF07_BC increased over time, B/B' decreased over time. CRF55_01B has increased in recent years, with higher pooled estimated rate in Guangdong (12.22%, 95% CI 10.34-13.17) and Fujian (8.65%, 95% CI 4.98-13.17) provinces. The distribution of HIV-1 subtypes among MSM in China has changed across different regions and periods. HIV-1 strains in MSM are becoming more complex. Long-term molecular monitoring in this population remains necessary for HIV-1 epidemic control and prevention.

Keywords: China; HIV-1; men who have sex with men; subtypes.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig. 1.
Fig. 1.
Flowchart of the study identification and selection process.
Fig. 2.
Fig. 2.
Temporal trends in the yearly proportion of different HIV-1 subtypes among MSM in China. The x-axis represents the midpoint of the year in which study samples were collected and analysed. The diameter of each bubble is proportional to the sample size of each study. The fitted line was plotted using locally weighted regression.
Fig. 3.
Fig. 3.
Estimated prevalence of different HIV-1 subtypes among MSM across the four regions in China during 2000–2016.
Fig. 4.
Fig. 4.
The pooled rate (%) of CRF01_AE, CRF07_BC and B/B′ among MSM in different provinces.
Fig. 5.
Fig. 5.
The pooled rate (%) of CRF08_BC, CRF_01B, C, URFs and CRF55_01B among MSM in different provinces.
See this image and copyright information in PMC

References

    1. Fact sheet – Latest statistics on the status of the AIDS epidemic Available at http://www.unaids.org/en/resources/fact-sheet.
    1. NCAIDS, NCSTD, CDC C (2018) Update on the AIDS/STD epidemic in China in December 2017. Chinese Journal of AIDS & STD, 111.
    1. Zeng Y et al. (1986) Detection of antibody to LAV/HTLV-III in sera from hemophiliacs in China. AIDS Research 2(suppl. 1), 24(173), S147–S149. - PubMed
    1. Lu L et al. (2008) The changing face of HIV in China. Nature 455, 609–611. - PubMed
    1. Wu Z et al. (2007) Evolution of China's response to HIV/AIDS. Lancet (London, England) 369, 679–690. - PMC - PubMed

Publication types