doi: 10.1039/c9nr00364a.
Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers
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- PMID: 30869719
- DOI: 10.1039/c9nr00364a
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Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers
Nanoscale.
.
Abstract
Circulating tumor cells (CTCs) are indicative for cancer diagnosis and prognosis. However, conventional immuno-magnetic cell capture technologies using antibody- and aptamer-functionalized magnetic particles generate increased intracellular oxidative stress through endocytosis. Herein, we efficiently, selectively, and non-invasively isolate CTCs from whole blood by mimicking double-sided tape using DNA.
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