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. 2019 Mar 28;11(13):5879-5883.
doi: 10.1039/c9nr00364a.

Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers

Yongli Chen  1 , Wei Wang, Deependra Tyagi, Andrew J Carrier, Shufen Cui, Shengnan He, Xu Zhang
Affiliations

Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers

Yongli Chen et al. Nanoscale. .

Abstract

Circulating tumor cells (CTCs) are indicative for cancer diagnosis and prognosis. However, conventional immuno-magnetic cell capture technologies using antibody- and aptamer-functionalized magnetic particles generate increased intracellular oxidative stress through endocytosis. Herein, we efficiently, selectively, and non-invasively isolate CTCs from whole blood by mimicking double-sided tape using DNA.

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