Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Apr 2;116(14):6528-6530.
doi: 10.1073/pnas.1902400116. Epub 2019 Mar 14.

Retinoic acid receptor plays both sides of homeostatic plasticity

Brandon J Walters  1   2   3   4 , Sheena A Josselyn  5   2   3   4   6
Affiliations
Comment

Retinoic acid receptor plays both sides of homeostatic plasticity

Brandon J Walters et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The many roles of RARα. (Top) Representation of RARα from ref. . (Middle) Three described functions of RARα: direct translational regulation (Left), direct transcriptional regulation (Center), and indirect translational regulation (Right). The transcriptional function of RARα has no known role in homeostatic synaptic plasticity (see Effect on HSP); however, both translational functions of RARα play important roles in HSP. The direct translational role of RARα (Bottom, Left) promotes the translation of AMPA receptors, which are inserted into the postsynaptic membrane after prolonged synaptic silencing, scaling up the synaptic response [illustrated by an increase in the evoked postsynaptic potential (EPSP)]. This is in direct opposition to the indirect translational role of RARα (Bottom, Right), which reduces translation of AMPA receptors by affecting the ERK-mTORC1 pathway, scaling down the synaptic response after persistent activity.
See this image and copyright information in PMC

Comment on

References

    1. Aoto J, Nam CI, Poon MM, Ting P, Chen L. Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron. 2008;60:308–320. - PMC - PubMed
    1. Hsu Y-T, Li J, Wu D, Südhof TC, Chen L. Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning. Proc Natl Acad Sci USA. 2019;116:7113–7122. - PMC - PubMed
    1. Bourguet W, et al. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. Mol Cell. 2000;5:289–298. - PubMed

Publication types

Substances

LinkOut - more resources