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Comment
. 2019 May;20(5):254-255.
doi: 10.1038/s41576-019-0110-x.

Cytosine base editors go off-target

Katharine H Wrighton  1
Affiliations
Comment

Cytosine base editors go off-target

Katharine H Wrighton. Nat Rev Genet. 2019 May.
No abstract available

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References

Original article
    1. Jin, S. et al. Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science https://doi.org/10.1126/science.aaw7166 (2019) - DOI - PubMed
    1. Zuo, E. et al. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science https://doi.org/10.1126/science.aav9973 (2019) - DOI - PubMed
Further reading
    1. Rees, H. A. & Liu, D. R. Base editing: precision chemistry on the genome and transcriptome of living cells. Nat. Rev. Genet. 19, 770–788 (2018) - DOI

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