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. 2019 May;285(5):524-532.
doi: 10.1111/joim.12886. Epub 2019 Mar 14.

Innate immunity, inflammation and tumour progression: double-edged swords

A Mantovani  1   2   3 , A Ponzetta  1 , A Inforzato  1   2 , S Jaillon  1   2
Affiliations

Innate immunity, inflammation and tumour progression: double-edged swords

A Mantovani et al. J Intern Med. 2019 May.

Abstract

Components of the cellular and the humoral arm of the immune system are essential elements of the tumour microenvironment (TME). The TME includes tumour-associated macrophages which have served as a paradigm for the cancer-promoting inflammation. Cytokines, IL-1 in particular, and complement have emerged as important players in tumour promotion. On the other hand, myeloid cells, innate lymphoid cells and complement have the potential, if unleashed, to mediate anticancer resistance. Targeting checkpoints restraining innate immunity, macrophages and natural killer (NK) cells in particular holds promise as a therapeutic strategy.

Keywords: inflammation; innate immunity; interleukin-1; macrophages; tumour microenvironment.

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Figures

Figure 1
Figure 1
Links between inflammation and cancer at tissue and organism level.
Figure 2
Figure 2
The macrophage balance. Macrophages can exert a dual function in the tumor microenvironment. In established clinical tumors the pro- tumor function of TAM prevail. Macrophages serve as a paradigm for tumor promoting inflammation
See this image and copyright information in PMC

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