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. 2018 Jul 27;84(2):239-249.
doi: 10.29024/aogh.911.

Prenatal Exposure to Endocrine Disruptors and Cardiometabolic Risk in Preschoolers: A Systematic Review Based on Cohort Studies

Daniela S Gutiérrez-Torres  1 , Albino Barraza-Villarreal  1 , Leticia Hernandez-Cadena  1 , Consuelo Escamilla-Nuñez  1 , Isabelle Romieu  1
Affiliations

Prenatal Exposure to Endocrine Disruptors and Cardiometabolic Risk in Preschoolers: A Systematic Review Based on Cohort Studies

Daniela S Gutiérrez-Torres et al. Ann Glob Health. .

Abstract

Background: Follow-up studies have reported both positive and negative associations between prenatal exposure to endocrine disrupting chemicals (EDCs) and some anthropometric indicators of overweight and obesity in children. However, few studies have evaluated the effect of this exposure on cardiometabolic risk factors in preschool-age children. The health and disease development paradigm (DOHaD) proposes that the physiological and metabolic adaptations triggered by the exposure to these compounds, coupled with postnatal conditions, can modify the risk of disease. In this context, cardiometabolic risk factors in children are not only an important outcome derived from prenatal exposure but a predictor/mediator of the children's future health.

Objective: To conduct a systematic review of the evidence published in the last 10 years from cohort studies on the association between prenatal exposure to EDCs and cardiometabolic risk factors in preschoolers.

Design: Studies published from January 1, 2007 to May 1, 2017 in PubMed were analyzed. The research strategy was based on specified keywords and following the application of strict inclusion/exclusion criteria, 16 studies were identified and reviewed. Data were extracted and aspects of quality were assessed using an adapted Newcastle-Ottawa scale for cohort studies.

Results: Only 5 of the 16 studies reviewed analyzed cardiometabolic risk factors in addition to anthropometric measures in children. The cohort studies included in this review suggest that prenatal exposure to low concentrations of EDCs has an impact on anthropometric variables and biochemical parameters in preschool-age children. Positive associations between prenatal exposure to EDCs and percentage of fat mass, body mass index, waist circumference, skinfolds and risk of overweight persisted after adjustment for important confounding variables. No association was found with lipid profile and glucose levels.

Conclusions: Evidence was found to suggest that prenatal exposure to EDCs is positively associated with cardiometabolic risk factors in preschool children.

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Conflict of interest statement

The authors have no competing interests to declare.

Figures

Figure 1
Figure 1
Flowchart for the selection of studies included in the systematic review.
See this image and copyright information in PMC

References

    1. Crisp TM, Clegg ED, Cooper RL, et al. Environmental endocrine disruption: An effects assessment and analysis. Environ Health Perspect. 1998; 106(Suppl 1): 11–56. DOI: 10.1289/ehp.98106s111 - DOI - PMC - PubMed
    1. Diamanti-Kandarakis E, Palioura E, Kandarakis SA and Koutsilieris M. The impact of endocrine disruptors on endocrine targets. Horm Metab Res Horm Stoffwechselforschung Horm Métabolisme. 2010; 42(8): 543–552. DOI: 10.1055/s-0030-1252034 - DOI - PubMed
    1. Grün F and Blumberg B. Environmental obesogens: Organotins and endocrine disruption via nuclear receptor signaling. Endocrinology. 2006; 147(6): s50–s55. DOI: 10.1210/en.2005-1129 - DOI - PubMed
    1. Eriksson JG. Developmental origins of health and disease – from a small body size at birth to epigenetics. Ann Med. 2016; 11–12. DOI: 10.1080/07853890.2016.1193786 - DOI - PubMed
    1. Wells G, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. July 2017. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

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