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Comment
. 2019 Jun;16(6):860-863.
doi: 10.1080/15476286.2019.1592072. Epub 2019 Mar 22.

MALAT1 long non-coding RNA and breast cancer

Gayatri Arun  1 , David L Spector  1
Affiliations
Comment

MALAT1 long non-coding RNA and breast cancer

Gayatri Arun et al. RNA Biol. 2019 Jun.

Abstract

Non-coding RNAs are becoming major players in disease pathogenesis such as cancer. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a nuclear enriched long non-coding RNA that is generally overexpressed in patient tumors and metastases. Overexpression of MALAT1 has been shown to be positively correlated with tumor progression and metastasis in a large number of tumor types including breast tumors. Surprisingly, a recent report by Kim et al shows a metastasis suppressive role for Malat1. Here, we discuss these results in the context of a large body of published literature that support a pro-tumorigenic role for MALAT1 in order to gain potential insights into the basis of these observed differences.

Keywords: LncRNA; MALAT1; breast cancer; metastasis.

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Comment on

  • Long noncoding RNA MALAT1 suppresses breast cancer metastasis.
    Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Kim J, et al. Nat Genet. 2018 Dec;50(12):1705-1715. doi: 10.1038/s41588-018-0252-3. Epub 2018 Oct 22. Nat Genet. 2018. PMID: 30349115 Free PMC article.

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