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Comment
. 2019 May;29(5):341-342.
doi: 10.1038/s41422-019-0156-5.

Tissue-resident memory T cells keep cancer dormant

Sarah Sharon Gabriel  1 , Axel Kallies  2
Affiliations
Comment

Tissue-resident memory T cells keep cancer dormant

Sarah Sharon Gabriel et al. Cell Res. 2019 May.
No abstract available

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Figures

Fig. 1
Fig. 1
a Tissue-resident CD8 memory cells (TRM) in the epidermal layer of the skin actively control subclinical melanomas for prolonged periods of time, thereby establishing and maintaining cancer-immune equilibrium. Circulatory T cells are largely excluded from the epidermis, the location where melanomas naturally arise. b During later stages of the disease, the vascularized tumor mass is infiltrated by CD8 T cells (tumor infiltrating lymphocytes, TILs) that often express inhibitory receptors such as PD-1 and show an exhausted phenotype
See this image and copyright information in PMC

Comment on

  • Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin.
    Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tüting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Hölzel M, Mackay LK, Waithman J, Gebhardt T. Park SL, et al. Nature. 2019 Jan;565(7739):366-371. doi: 10.1038/s41586-018-0812-9. Epub 2018 Dec 31. Nature. 2019. PMID: 30598548

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