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Comment
. 2019 May;597(9):2323-2324.
doi: 10.1113/JP277784. Epub 2019 Apr 2.

Is the fountain of youth in the gut microbiome?

John F Cryan  1   2 , Marcus Boehme  1 , Timothy G Dinan  1   3
Affiliations
Comment

Is the fountain of youth in the gut microbiome?

John F Cryan et al. J Physiol. 2019 May.
No abstract available

Keywords: Ageing; Cardiovascular Physiology; Microbiome.

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Figures

Figure 1
Figure 1. The gut microbiome and body's systems in ageing
A growing body of evidence supports the concept that changes in microbiota composition in ageing may be causally related to age‐related changes in cardiovascular, immune, gastrointestinal and brain health. CVD, cardiovascular disease; LPS, lipopolysaccharide; DAMPs, damage‐associated molecular patterns; SCFA, short‐chain fatty acid; TMAO, trimethylamine N‐oxide; FMT, faecal microbiota transplant.
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References

    1. Brunt VE, Gioscia‐Ryan RA, Richey JJ, Zigler MC, Cuevas LM, Gonzalez A, Vazquez‐Baeza Y, Battson ML, Smithson AT, Gilley AD, Ackermann G, Neilson AP, Weir T, Davy KP, Knight R & Seals DR (2019). Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice. J Physiol 597, 2361–2378. - PMC - PubMed
    1. Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O'Sullivan O, Fitzgerald GF, Deane J, O'Connor M, Harnedy N, O'Connor K, O'Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP & O'Toole PW (2012). Gut microbiota composition correlates with diet and health in the elderly. Nature 488, 178–184. - PubMed
    1. Dinan TG & Cryan JF (2017). Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration. J Physiol 595, 489–503. - PMC - PubMed
    1. Scott KA, Ida M, Peterson VL, Prenderville JA, Moloney GM, Izumo T, Murphy K, Murphy A, Ross RP, Stanton C, Dinan TG & Cryan JF (2017). Revisiting Metchnikoff: age‐related alterations in microbiota–gut–brain axis in the mouse. Brain Behav Immun 65, 20–32. - PubMed
    1. Thevaranjan N, Puchta A, Schulz C, Naidoo A, Szamosi JC, Verschoor CP, Loukov D, Schenck LP, Jury J, Foley KP, Schertzer JD, Larche MJ, Davidson DJ, Verdu EF, Surette MG & Bowdish DME (2017). Age‐associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction. Cell Host Microbe 21, 455–466 e4. - PMC - PubMed

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