Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 15;10(1):94.
doi: 10.1186/s13287-019-1203-3.

Skin tissue regeneration for burn injury

Anastasia Shpichka  1 , Denis Butnaru  2 , Evgeny A Bezrukov  3 , Roman B Sukhanov  3 , Anthony Atala  4 , Vitaliy Burdukovskii  5 , Yuanyuan Zhang  4 , Peter Timashev  6   7   8
Affiliations
Review

Skin tissue regeneration for burn injury

Anastasia Shpichka et al. Stem Cell Res Ther. .

Abstract

The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction between cell types, cytokines, mediators, the neurovascular system, and matrix remodeling. Tissue regeneration technology remarkably enhances skin repair via re-epidermalization, epidermal-stromal cell interactions, angiogenesis, and inhabitation of hypertrophic scars and keloids. The success rates of skin healing for burn injuries have significantly increased with the use of various skin substitutes. In this review, we discuss skin replacement with cells, growth factors, scaffolds, or cell-seeded scaffolds for skin tissue reconstruction and also compare the high efficacy and cost-effectiveness of each therapy. We describe the essentials, achievements, and challenges of cell-based therapy in reducing scar formation and improving burn injury treatment.

Keywords: Burns; Cell-based therapy; Skin regeneration; Skin substitutes; Stem cells.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Procedure of autologous stem cell-based therapy on burn injury
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Church D, Elsayed S, Reid O, Winston B, Lindsay R. Burn wound infections 2006;19:403–434. - PMC - PubMed
    1. Atiyeh BS, Costagliola M. Cultured epithelial autograft (CEA) in burn treatment: three decades later. Burns. 2007;33:405–413. - PubMed
    1. Wood FM, Kolybaba ML, Allen P. The use of cultured epithelial autograft in the treatment of major burn injuries: a critical review of the literature. Burns. 2006;32:395–401. - PubMed
    1. Nejati R, Kovacic D, Slominski A. Neuro-immune-endocrine functions of the skin: An overview. Expert Rev Dermatol. 2013;8:581–583. - PMC - PubMed
    1. Mathes SH, Ruffner H, Graf-Hausner U. The use of skin models in drug development. Adv Drug Deliv Rev. 2014;69–70:81–102. doi: 10.1016/j.addr.2013.12.006. - DOI - PubMed

Publication types