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. 2019 Dec;17(13):2816-2818.
doi: 10.1016/j.cgh.2019.02.045. Epub 2019 Mar 12.

Crohn's Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping

Scott McHenry  1 , Yeshika Sharma  2 , Ankita Tirath  3 , Richard Tsai  4 , Aaron Mintz  4 , Tyler J Fraum  4 , Amber Salter  5 , Jeffrey D Browning  6 , Avegail G Flores  1 , Nicholas O Davidson  1 , Kathryn J Fowler  7 , Matthew A Ciorba  8 , Parakkal Deepak  9
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Crohn's Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping

Scott McHenry et al. Clin Gastroenterol Hepatol. 2019 Dec.

Abstract

Nonalcoholic fatty liver disease (NAFLD) commonly coexists with Crohn's disease (CD); however, it remains unclear if it is more prevalent than would be expected as ultrasound surveys of CD patients report a very wide range of prevalence (9%-40%).1-3 To address this uncertainty, we performed a prospective, cross-sectional survey of NAFLD in CD patients by generating magnetic resonance proton density fat fraction (MR-PDFF) maps as compared with 2 control populations. MR-PDFF provides a quantitative, sensitive and specific (97% and 100%, respectively) radiographic surrogate for liver fat.4.

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Figures

Figure 1:
Figure 1:
A Overall Rates of NAFLD are Higher in Crohn’s Disease B Crohn’s Disease Patients Have Higher Rates of NAFLD with an Elevated Fibrosis-4 Score Footnotes: NAFLD, nonalcoholic fatty liver disease; BMI, body mass index; DHS, Dallas Heart Study
See this image and copyright information in PMC

References

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