Review

. 2019 Apr;26(2):85-100.

doi: 10.1007/s40292-019-00306-8. Epub 2019 Mar 15.

Latest Updates on Lipid Management

Emmanuel Eroume-A Egom^{1

2}, Rebabonye B Pharithi³, Soressa Hesse³, Neasa Starr³, Richard Armstrong³, Habitha Mohammed Sulaiman³, Katarina Gazdikova^{4

5}, Ioana Mozos⁶, Martin Caprnda⁷, Peter Kubatka⁸, Peter Kruzliak^{9

10}, Barkat Khan³, Ludovit Gaspar¹¹, Vincent M G Maher¹²

Affiliations

¹ Department of Clinical Medicine, Education Division, School of Medicine, Trinity College Dublin, Dublin, Ireland. egom@ectrs.ca.
² Department of Cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National Children Hospital, Tallaght Hospital, Tallaght, Dublin 24, Ireland. egom@ectrs.ca.
³ Department of Cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National Children Hospital, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
⁴ Department of Nutrition, Faculty of Nursing and Professional Health Studies, Slovak Medical University, Limbova 12, 833 03, Bratislava, Slovakia. katarina.gazdikova@szu.sk.
⁵ Department of General Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia. katarina.gazdikova@szu.sk.
⁶ Department of Functional Sciences, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
⁷ 1st Department of Internal Medicine, Comenius University and University Hospital, Mickiewiczova 2247/13, 811 07, Bratislava, Slovakia.
⁸ Department of Biology, Jessenius Faculty of Medicine in Martin, Comenius Universityin Bratislava, Martin, Slovakia.
⁹ Department of Internal Medicine, Brothers of Mercy Hospital, Polni 3, 63900, Brno, Czech Republic. kruzliakpeter@gmail.com.
¹⁰ 2nd Department of Surgery, Faculty of Medicine, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic. kruzliakpeter@gmail.com.
¹¹ 1st Department of Internal Medicine, Comenius University and University Hospital, Mickiewiczova 2247/13, 811 07, Bratislava, Slovakia. ludovitgaspar@gmail.com.
¹² Department of Cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National Children Hospital, Tallaght Hospital, Tallaght, Dublin 24, Ireland. vmaher@gmail.com.

PMID: 30877603
DOI: 10.1007/s40292-019-00306-8

Review

Latest Updates on Lipid Management

Emmanuel Eroume-A Egom et al. High Blood Press Cardiovasc Prev. 2019 Apr.

. 2019 Apr;26(2):85-100.

doi: 10.1007/s40292-019-00306-8. Epub 2019 Mar 15.

Authors

Affiliations

¹ Department of Clinical Medicine, Education Division, School of Medicine, Trinity College Dublin, Dublin, Ireland. egom@ectrs.ca.
² Department of Cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National Children Hospital, Tallaght Hospital, Tallaght, Dublin 24, Ireland. egom@ectrs.ca.
³ Department of Cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National Children Hospital, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
⁴ Department of Nutrition, Faculty of Nursing and Professional Health Studies, Slovak Medical University, Limbova 12, 833 03, Bratislava, Slovakia. katarina.gazdikova@szu.sk.
⁵ Department of General Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia. katarina.gazdikova@szu.sk.
⁶ Department of Functional Sciences, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
⁷ 1st Department of Internal Medicine, Comenius University and University Hospital, Mickiewiczova 2247/13, 811 07, Bratislava, Slovakia.
⁸ Department of Biology, Jessenius Faculty of Medicine in Martin, Comenius Universityin Bratislava, Martin, Slovakia.
⁹ Department of Internal Medicine, Brothers of Mercy Hospital, Polni 3, 63900, Brno, Czech Republic. kruzliakpeter@gmail.com.
¹⁰ 2nd Department of Surgery, Faculty of Medicine, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic. kruzliakpeter@gmail.com.
¹¹ 1st Department of Internal Medicine, Comenius University and University Hospital, Mickiewiczova 2247/13, 811 07, Bratislava, Slovakia. ludovitgaspar@gmail.com.
¹² Department of Cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National Children Hospital, Tallaght Hospital, Tallaght, Dublin 24, Ireland. vmaher@gmail.com.

PMID: 30877603
DOI: 10.1007/s40292-019-00306-8

Abstract

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide. Despite the clinical long-term and near-term benefits of lowering cholesterol in, respectively, primary and secondary prevention of ASCVD, cholesterol levels remain under-treated, with many patients not achieving their recommended targets. The present article will review the latest updates on lipid management with emphases on the different classes of cholesterol-lowering agents and their clinical uses.

Keywords: ASCVD; Atherosclerotic cardiovascular disease; Cholesterol; Lipid management; Triglycerides.

PubMed Disclaimer

Cited by

Rosuvastatin protects against endothelial cell apoptosis in vitro and alleviates atherosclerosis in ApoE^-/- mice by suppressing endoplasmic reticulum stress.
Geng J, Xu H, Fu W, Yu X, Xu G, Cao H, Lin G, Sui D. Geng J, et al. Exp Ther Med. 2020 Jul;20(1):550-560. doi: 10.3892/etm.2020.8733. Epub 2020 May 8. Exp Ther Med. 2020. PMID: 32537013 Free PMC article.
Generation of a Novel High-Affinity Antibody Binding to PCSK9 Catalytic Domain with Slow Dissociation Rate by CDR-Grafting, Alanine Scanning and Saturated Site-Directed Mutagenesis for Favorably Treating Hypercholesterolemia.
Bai Z, Xu M, Mei Y, Hu T, Zhang P, Chen M, Lv W, Lu C, Tan S. Bai Z, et al. Biomedicines. 2021 Nov 27;9(12):1783. doi: 10.3390/biomedicines9121783. Biomedicines. 2021. PMID: 34944600 Free PMC article.
Lipid-lowering Therapies in Myositis.
Mizus MC, Tiniakou E. Mizus MC, et al. Curr Rheumatol Rep. 2020 Aug 26;22(10):70. doi: 10.1007/s11926-020-00942-3. Curr Rheumatol Rep. 2020. PMID: 32845379 Free PMC article. Review.
Ginsenoside Rg3 Alleviates ox-LDL Induced Endothelial Dysfunction and Prevents Atherosclerosis in ApoE^-/- Mice by Regulating PPARγ/FAK Signaling Pathway.
Geng J, Fu W, Yu X, Lu Z, Liu Y, Sun M, Yu P, Li X, Fu L, Xu H, Sui D. Geng J, et al. Front Pharmacol. 2020 Apr 22;11:500. doi: 10.3389/fphar.2020.00500. eCollection 2020. Front Pharmacol. 2020. PMID: 32390845 Free PMC article.

References

1. N Engl J Med. 1999 Aug 12;341(7):498-511 - PubMed
1. BMJ. 1999 Dec 11;319(7224):1523-8 - PubMed
1. Am J Cardiol. 2000 Jul 15;86(2):221-3 - PubMed
1. Am J Clin Nutr. 2000 Nov;72(5):1128-34 - PubMed
1. J Cell Mol Med. 2001 Oct-Dec;5(4):378-87 - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Latest Updates on Lipid Management

Affiliations

Latest Updates on Lipid Management

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical