Synthesis of methionine methyl ester-modified coumarin as the fluorescent-colorimetric chemosensor for selective detection Cu2+ with application in molecular logic gate

Abstract

A methionine methyl ester-modified coumarin derivative was designed and synthesized, which could discriminate Cu²⁺ from other metal ions in HEPES buffer (10 mM, pH 7.4)/CH₃CN (40:60, V/V). The detection limit of WM toward Cu²⁺ was 1.84 × 10^-7 M, which was lower than the concentration of Cu²⁺ in drinking water suggested by WHO and EPA. And the proposed coordination mode exhibiting the interaction between WM and Cu²⁺ was studied by UV-Vis, fluorescence spectrum, ESI-MS and FT-IR. Based on the fluorescent reversibility of WM, WM was considered as a molecular logic gate and molecular keypad lock. In addition, the test strips and the silica gel plates prepared from the solution of WM also demonstrate the favorable selectivity toward Cu²⁺.

Keywords: Coumarin; Cu(2+); Fluorescent probes; IMPLICATION logic gate; Silica gel plates; Test strips.