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Review
. 2019 Jul;81(1):297-305.
doi: 10.1016/j.jaad.2019.03.009. Epub 2019 Mar 13.

Navigating the landscape of core outcome set development in dermatology

Cecilia A C Prinsen  1 , Phyllis I Spuls  2 , Jan Kottner  3 , Kim S Thomas  4 , Christian Apfelbacher  5 , Joanne R Chalmers  4 , Stefanie Deckert  6 , Masutaka Furue  7 , Louise Gerbens  2 , Jamie Kirkham  8 , Eric L Simpson  9 , Murad Alam  10 , Katrin Balzer  11 , Dimitri Beeckman  12 , Viktoria Eleftheriadou  4 , Khaled Ezzedine  13 , Sophie E R Horbach  14 , John R Ingram  15 , Alison M Layton  16 , Karsten Weller  17 , Thomas Wild  18 , Albert Wolkerstorfer  2 , Hywel C Williams  4 , Jochen Schmitt  6
Affiliations
Review

Navigating the landscape of core outcome set development in dermatology

Cecilia A C Prinsen et al. J Am Acad Dermatol. 2019 Jul.

Abstract

The development of core outcome sets (COSs; ie, a minimum set of core outcomes that should be measured and reported in all trials or in clinical practice for a specific condition) in dermatology is increasing in pace. A total of 44 dermatology-related COS projects have been registered in the online Core Outcome Measures in Effectiveness Trials database (http://www.comet-initiative.org/studies/search) and include studies on 26 different skin diseases. With the increasing number of COSs in dermatology, care is needed to ensure the delivery of high-quality COSs that meet quality standards when using state-of-the-art methods. In 2015, the Cochrane Skin-Core Outcome Set Initiative (CS-COUSIN) was established. CS-COUSIN is an international, multidisciplinary working group aiming to improve the development and implementation of COSs in dermatology. CS-COUSIN has developed guidance on how to develop high-quality COSs for skin diseases and supports dermatology-specific COS initiatives. Currently, 17 COS development groups are affiliated with CS-COUSIN and following standardized COS development processes. To ensure successful uptake of COSs in dermatology, researchers, clinicians, systematic reviewers, guideline developers, and other stakeholders should use existing COSs in their work.

Keywords: CS-COUSIN; Cochrane Skin; clinical trials; core outcome set; dermatology; development; implementation.

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