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Review
. 2019 Sep;24(9):1731-1734.
doi: 10.1016/j.drudis.2019.03.014. Epub 2019 Mar 14.

Oxidative phosphorylation inducers fight pathological angiogenesis

M Pilar Bayona-Bafaluy  1 , Olivia Esteban  2 , Javier Ascaso  2 , Julio Montoya  3 , Eduardo Ruiz-Pesini  4
Affiliations
Review

Oxidative phosphorylation inducers fight pathological angiogenesis

M Pilar Bayona-Bafaluy et al. Drug Discov Today. 2019 Sep.

Abstract

Pathological mutations in subunits of the oxidative phosphorylation (OXPHOS) system, or inhibitors of this biochemical pathway, increase the production of vascular endothelial growth factor (VEGF) and pathological angiogenesis. In many angiogenesis-related diseases, such as retinal, rheumatoid diseases, or cancer, OXPHOS dysfunction can be found. Thus, enhancing OXPHOS might be a promising therapeutic approach for pathologic angiogenesis.

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