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. 2019 Apr;17(4):3960-3964.
doi: 10.3892/ol.2019.10026. Epub 2019 Feb 7.

Association of an miR-502-binding site polymorphism in the 3'-untranslated region of SET8 with colorectal cancer

Shuang Liu  1 , Hailing Dong  2 , Jianhua Wu  3 , Cuiju Wang  4
Affiliations

Association of an miR-502-binding site polymorphism in the 3'-untranslated region of SET8 with colorectal cancer

Shuang Liu et al. Oncol Lett. 2019 Apr.

Abstract

The histone methyltransferase SET8 is regulated by microRNA-502 through the binding site in its 3'-untranslated region, and the rs16917496 polymorphism at the miR-502-binding site in the SET8 gene has been implicated in a number of cancer types. The rs16917496 polymorphism including CC, CT and TT genotypes was analyzed in patients with colorectal cancer; the CC genotype was identified to be independently associated with longer post-operative survival times using multivariate analysis (relative risk, 2.406; 95% confidence interval, 1.017-5.691; P=0.046). In addition, decreased SET8 expression was associated with the SET8 CC genotype and longer survival times for patients with colorectal cancer. The results of the present study indicated that miR-502 mediates SET8 expression at least partly by altering the binding affinity between miR-502 and SET8 so as to modify the colorectal cancer outcome. The results indicate that SET8 may be a novel target for colorectal cancer therapy.

Keywords: SET8; colorectal cancer; microRNA-502; polymorphism.

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Figures

Figure 1.
Figure 1.
Significant difference in survival time for patients with colorectal cancer with the CC and CT + TT genotypes of rs16917496. Cum, cumulative.
Figure 2.
Figure 2.
SET8 expression in patients with CRC. (A) Low SET8 expression with an HScore of 40 for the SET8 CC genotype in CRC tissues. (B) High SET8 expression with an HScore of 300 for the SET8 TT genotype in CRC tissues. Original magnification, ×400. CRC, colorectal cancer.
See this image and copyright information in PMC

References

    1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F, editors. Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012 v1.0. IARC CancerBase. http://globocan.iarcfr 2014;(11) IARC, Lyon.
    1. Center MM, Jemal A, Ward E. International trends in colorectal cancer incidence rates. CancerEpidemiol Biomarkers Prev. 2009;18:1688–1694. doi: 10.1158/1055-9965.EPI-09-0090. - DOI - PubMed
    1. World Cancer Research Fund, American Institute for Cancer Research Imperial College, London, corp-author. WCRF/AICR Systematic Literature Review Continuous Update Project Report: The Associations between Food, Nutrition and Physical Activity and the Risk of Colorectal Cancer. https://www.wcrf.org/sites/default/files/SLR_colorectal_cancer_2010.pdf. [Oct;2010 ];
    1. Bishehsari F, Mahdavinia M, Vacca M, Malekzadeh R, Mariani-Costantini R. Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol. 2014;20:6055–6072. doi: 10.3748/wjg.v20.i20.6055. - DOI - PMC - PubMed
    1. Migliore L, Migheli F, Spisni R, Coppedè F. Genetics, cytogenetics, and epigenetics of colorectal cancer. J Biomed Biotechnol. 2011;2011:792362. doi: 10.1155/2011/792362. - DOI - PMC - PubMed