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Case Reports
. 2019 Jan;12(1):35-37.
Epub 2019 Jan 1.

Paronychia Associated with Ledipasvir/Sofosbuvir for Hepatitis C Treatment

Blake Sampson  1   2 , Bethany K H Lewis  1   2
Affiliations
Case Reports

Paronychia Associated with Ledipasvir/Sofosbuvir for Hepatitis C Treatment

Blake Sampson et al. J Clin Aesthet Dermatol. 2019 Jan.

Abstract

We present a case of medication-associated paronychia involving multiple toenails in a patient undergoing hepatitis C (HCV) therapy with ledipasvir/sofosbuvir. The patient was treated conservatively with topical mupirocin, clobetasol ointment, and acetic acid soaks, resulting in symptom improvement and control. This topical regimen was maintainined throughout the remaining weeks of the patient's antiviral course, with complete symptom resolution occurring only after completion of his ledipasvir/sofosbuvir treatment.

Keywords: HCV; Harvoni®; Paronychia; hepatitis C; lepidasvir; sofosbuvir.

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Conflict of interest statement

FUNDING:No funding was provided for the preparation of this article. DISCLOSURES:The authors have no conflicts of interest relevant to the content of this article.

Figures

FIGURE 1.
FIGURE 1.
Paronychia of the bilateral first toes
FIGURE 2.
FIGURE 2.
Evidence of resolving paronychia on the right third finger
FIGURE 3.
FIGURE 3.
Improvement in paronychia after four weeks of conservative management while continuing on treatment with ledipasvir/sofosbuvir
See this image and copyright information in PMC

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