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. 1986 Jul 1;164(1):363-8.
doi: 10.1084/jem.164.1.363.

Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells

S H Kaufmann, E Hug, G De Libero

Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells

S H Kaufmann et al. J Exp Med. .

Abstract

Lyt-2+ T cell clones were established from Listeria monocytogenes-infected mice. The clones secreted IFN-gamma after stimulation with spleen cells from L. monocytogenes-infected mice plus IL-2. Spleen cells from normal mice were not stimulatory. Furthermore, cloned T cells lysed L. monocytogenes-infected macrophages. Cytolysis was antigen-specific and H-2K-restricted. These findings suggest a role for specific cytotoxic T cells in the immune response to intracellular bacteria.

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