Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Mar 6;76(1):59-62.
doi: 10.31053/1853.0605.v76.n1.21959.

[Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept]

[Article in Spanish]
Damian Jesus Malano  1 , Ingrid Strusberg
Affiliations
Case Reports

[Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept]

[Article in Spanish]
Damian Jesus Malano et al. Rev Fac Cien Med Univ Nac Cordoba. .

Abstract
in English, Spanish

Introduction: There are numerous reports of patients with rheumatoid arthritis (RA) who became pregnant while on treatment with etanercept. In spite of being formally contraindicated during pregnancy and lactation its discontinuation in cases of women with severe RA is no longer recommended since an increase in congenital malformations nor perinatal complications has not been reported. There are few data on the success or failure of pregnancies achieved by assisted fertilization in patients with RA treated with etanercept.

Methods: Two cases of severe RA under etanercept treatment and assisted fertilization are described.

Results: After 4 failed attempts both patients became pregnant. They finally arrived at term without obstetric or perinatal complications. No congenital malformations nor infectious complications of the newborns occurred.

Conclusion: The risk-benefit profile of etanercept in severe RA patients has been changing with postmarketing surveillance. If there is clinical indication, the benefit of not stopping etanercept during assited fertilization and pregnancy should be .evaluated.

Introducción: Existen numerosos reportes de pacientes con artritis reumatoidea (AR) que quedaron embarazadas mientras se encontraban en tratamiento con etanercept. Si bien se encuentra formalmente contraindicado durante embarazo y lactancia, su suspensión en casos de mujeres con AR severa ya no se aconseja debido a que no se ha reportado un aumento de malformaciones congénitas ni de complicaciones perinatales. Existen pocos datos acerca del éxito o fracaso de embarazos logrados por fertilización asistida en pacientes con AR en tratamiento con etanercept.

Métodos: Se describen dos casos clínicos de pacientes con AR severa en tratamiento con etanercept que realizaron técnicas de fertilización in vitro.

Resultados: Tras 4 intentos fallidos, ambas pacientes cursaron embarazos sin complicaciones obstétricas ni perinatales y no se registraron malformaciones congénitas ni complicaciones infectológicas en los recién nacidos.

Conclusión: El perfil riesgo-beneficio de etanercept en pacientes con AR severa ha ido cambiando con la farmacovigilancia poscomercialización. Si existe indicación clínica, debe evaluarse el beneficio de no suspenderlo en el curso de tratamientos de fertilización asistida y embarazo.

Keywords: etanercept; in vitro fertilization; rheumatoid arthritis.

PubMed Disclaimer

Publication types

LinkOut - more resources