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Randomized Controlled Trial
. 2019 Mar 18;19(1):37.
doi: 10.1186/s12871-019-0708-8.

Comparison of intravenous lidocaine and dexmedetomidine infusion for prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial

S Y Li  1 , H Li  1 , J Ni  2 , Y S Ma  1
Affiliations
Randomized Controlled Trial

Comparison of intravenous lidocaine and dexmedetomidine infusion for prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial

S Y Li et al. BMC Anesthesiol. .

Abstract

Background: Catheter-related bladder discomfort (CRBD) frequently occurs during recovery in patients who undergo intra-operative urinary catheterization. We conducted this study to compare the effect of intravenous lidocaine and dexmedetomidine infusion for preventing CRBD.

Methods: 120 patients undergoing elective open abdominal hysterectomy or hysteromyomectomy requiring urinary bladder catheterization were randomly allocated into three groups of 40 each. Group L received a 2 mg/kg lidocaine bolus followed by infusion of 1.5 mg/kg/h; Group D received a 0.5 μg/kg dexmedetomidine bolus followed by infusion of 0.4 μg/kg/h; Group C received a bolus and infusion of normal saline of equivalent volume. The incidence and different severity (mild, moderate, and severe) of CRBD were assessed on arrival in the postanaesthesia care unit at 0, 1, 2, and 6 h postoperatively.

Results: The incidence of CRBD was significantly lower in Group L and Group D compared with Group C at 0, 1, and 2 h. However, there was no significant difference among the three groups regarding the different severity of CRBD at all time points. The requirement of rescue tramadol for CRBD was lower in group L and group D than in group C. The incidence of sedation was significantly higher in Group D compared to Group L and Group C, though no difference in other adverse effects was observed.

Conclusions: Intravenous lidocaine and dexmedetomidine infusion reduced the incidence of CRBD as well as the additional tramadol requirement for CRBD, but had no effect on the different severity of CRBD.

Trial registration: ChiCTR-INR-16009162 . Registered on 5 September 2016.

Keywords: Catheter-related bladder discomfort; Dexmedetomidine; Lidocaine.

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Conflict of interest statement

Ethics approval and consent to participate

Ethical approval for China Ethics Committee of Registering Clinical Trials (ChiECRCT-2,016,043) and registered in the Chinese Clinical Trial Registry (ChiCTR-INR-16009162, date of registration: 2016-9-5) prior to patient enrollment. Written informed consent was abtained from all patients.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
CONSORT flow diagram
Fig. 2
Fig. 2
Adverse effects among the three groups (presented as numbers). &P < 0.05, There is significant difference between group L and group D.*P < 0.05, There is significant difference between group D and group C. #P < 0.05, There is significant difference between group L and group C
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