Pediatric glial fibrillary acidic protein meningoencephalomyelitis: A case report and review of the literature

Abstract

A novel autoantibody, glial fibrillary acidic protein (GFAP)-IgG, has recently been associated with cases of meningoencephalomyelitis. This entity is still being unraveled. Very few pediatric patients have been identified; thus, the clinical, biological and imaging phenotype remains to be defined. Herein we describe the clinical course of a 6-year-old patient initially suspected to have a demyelinating disease but ultimately diagnosed with GFAP-IgG positive autoimmune meningoencephalomyelitis. We also provide a review of the literature regarding this novel entity.

Keywords: Case report; GFAP; Glial fibrillary acidic protein; Meningoencephalomyelitis; Pediatric.