Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Dec;17(13):2800-2802.
doi: 10.1016/j.cgh.2019.03.009. Epub 2019 Mar 15.

Combination Therapy With Elimination Diet and Corticosteroids Is Effective for Adults With Eosinophilic Esophagitis

Craig C Reed  1 , Manaswita Tappata  1 , Swathi Eluri  1 , Nicholas J Shaheen  1 , Evan S Dellon  2
Affiliations

Combination Therapy With Elimination Diet and Corticosteroids Is Effective for Adults With Eosinophilic Esophagitis

Craig C Reed et al. Clin Gastroenterol Hepatol. 2019 Dec.

Abstract

Eosinophilic esophagitis (EoE) is a chronic immune/antigen-mediated disorder defined by eosinophilic-predominant inflammation and esophageal dysfunction.1,2 EoE represents an important cause of esophageal morbidity and a leading cause of esophagitis.3.

PubMed Disclaimer

Conflict of interest statement

Potential competing interests: Dr. Dellon is a consultant for Adare, Alivio, Allakos, AstraZeneca, Banner, Calypso, Enumeral, EsoCap, Gossamer Bio, GSK, Receptos/Celegene, Regeneron, Robarts, and Shire, receives research funding from Adare, Allakos, GSK, Meritage, Miraca, Nutricia, Receptos/Celgene, Regeneron, and Shire, and has received an educational grant from Allakos, Banner, and Holoclara. None of the other authors report and potential conflicts of interest with this study.

Figures

Figure 1
Figure 1
A. Proportion of patients reporting clinical symptoms prior to combined treatment, as well as immediately following the initial combined treatment course, and the last available report while on combined treatment. Figure 1B. Proportion of individual endoscopic findings prior to combined treatment, as well as immediately following the initial combined treatment course, and the last available report while on combined treatment. Figure 1C. Box plots depicting eosinophil counts prior to combined treatment, as well as immediately following the initial combined treatment course, and the last available report while on combined treatment. Figure 1D. Clinical and histologic responses to monotherapy with food elimination diet or topical corticosteroids prior to combined therapy. **Note: There were an additional two patients treated with topical corticosteroids reporting treatment-related side effects (e.g. irritability) prompting discontinuation.
See this image and copyright information in PMC

References

    1. Dellon ES, Gonsalves N, Hirano I, et al. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol. 2013;108(5):679–92. - PubMed
    1. Lucendo AJ, Molina-Infante J, Arias Á, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United Eur Gastroenterol J. 2017;5(3):335–358. - PMC - PubMed
    1. Dellon ES, Hirano I. Epidemiology and Natural History of Eosinophilic Esophagitis. Gastroenterology. 2017;154(2):319–332. - PMC - PubMed
    1. Reed CC, Fan C, Koutlas NT, et al. Food elimination diets are effective for long-term treatment of adults with eosinophilic oesophagitis. Aliment Pharmacol Ther. 2017;46(9):836–844. - PMC - PubMed
    1. Dellon E Management of refractory eosinophilic oesophagitis. Nat Rev Gastroenterol Hepatol. 2017;14(8):479–490. - PMC - PubMed

Publication types