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Review
. 2019 Apr 12;39(4):BSR20190527.
doi: 10.1042/BSR20190527. Print 2019 Apr 30.

The function of histone acetylation in cervical cancer development

Shanshan Liu  1 , Weiqin Chang  2 , Yuemei Jin  1 , Chunyang Feng  1 , Shuying Wu  1 , Jiaxing He  1 , Tianmin Xu  3
Affiliations
Review

The function of histone acetylation in cervical cancer development

Shanshan Liu et al. Biosci Rep. .

Abstract

Cervical cancer is the fourth most common female cancer in the world. It is well known that cervical cancer is closely related to high-risk human papillomavirus (HPV) infection. However, epigenetics has increasingly been recognized for its role in tumorigenesis. Epigenetics refers to changes in gene expression levels based on non-gene sequence changes, primarily through transcription or translation of genes regulation, thus affecting its function and characteristics. Typical post-translational modifications (PTMs) include acetylation, propionylation, butyrylation, malonylation and succinylation, among which the acetylation modification of lysine sites has been studied more clearly so far. The acetylation modification of lysine residues in proteins is involved in many aspects of cellular life activities, including carbon metabolism, transcriptional regulation, amino acid metabolism and so on. In this review, we summarize the latest discoveries on cervical cancer development arising from the aspect of acetylation, especially histone acetylation.

Keywords: Cervical cancer; Epigenetics; Histone acetylation.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Histone acetylation and deacetylation
See this image and copyright information in PMC

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