Lack of association between matrix metalloproteinase-1 gene rs1799750 polymorphism and osteoarthritis susceptibility: a meta-analysis

Abstract

Background. A relationship between matrix metalloproteinase-1 (MMP-1)-1607 (rs1799750) gene polymorphism and osteoarthritis (OA) susceptibility was reported in the Bioscience Reports journal; however, these results were inconsistent. To evaluate the specific relationship, we used a meta-analysis study to clarify the controversy. Methods. The relevant articles were retrieved on 20 October 2018 from PubMed, Elsevier, Springer, Ebase (Ovid), and Google Scholar. The number of alleles and genotypes for MMP-1 was obtained. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between MMP-1-1607 (rs1799750) 1G/2G promoter polymorphism and OA, while the Egger's test was used to assess heterogeneity among studies and publication bias. All statistical analyses were conducted using STATA 12.0 software. Results. A total of six case-control studies covering 1133 cases and 1119 controls were included in the final meta-analysis. There was no significant association between MMP-1-1607 1G/2G promoter polymorphism and OA in all genetic models (2G versus 1G: OR = 1.12, 95% CI = 0.78-1.60; 1G/2G versus 1G/1G: OR = 0.73, 95% CI = 0.32-1.67; 2G/2G versus 1G/1G: OR = 1.31, 95% CI = 0.57-2.98; the recessive model: OR = 1.23, 95% CI = 0.63-2.41; and the dominant model: OR = 1.25, 95% CI = 0.79-1.97). We obtained similar results for the subgroup analysis using ethnicity and type of disease. Conclusion. We systematically investigated the association between MMP-1-1607 (rs1799750) 1G/2G polymorphism and OA susceptibility; however, the results show no correlation.

Keywords: MMP-1; gene; osteoarthritis; polymorphism.

Figure 1. Studies identification diagram

Figure 2. Funnel plots of the association betwen MMP-1-1607 (rs1799750) 1G/2G polymorphism and OA

(A) Alleles model: 2G versus 1G; (B) Dominant model: 2G/2G+1G/2G versus 1G/1G; (C) Recessive model: 2G/2G versus 1G/2G + 1G/1G; (D) Alleles model: 1G/2G versus 2G/2G; (E) Alleles model: 2G/2G versus 1G/1G .