[Antiphlogistic effectiveness of combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases of the arachidonic acid cascade]

Abstract

Combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenase as the key enzymes of the arachidonic acid cascade were investigated with respect to their anti-inflammatory effectivity in the carrageenin paw edema and adjuvant arthritis of rats. Combinations of indometacin with butylhydroxytoluene, quinacrine, lidocaine or/and procaine gave additive or overadditive effects in the carrageenin edema. Addition of ascorbic acid decreased the effectivity. Similar results as with indometacin were obtained with dexamethasone. The "steroid saving effect" of the combination of a glucocorticoid with a non-steroidal anti-inflammatory analgesic was confirmed in the carrageenin edema. However, it could not be found in the adjuvant arthritic rat with dexamethasone and declofenac-Na. The fitness of the models is discussed.