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. 1986;89(2):259-60.
doi: 10.1007/BF00310640.

Antagonism of apomorphine-induced yawning by SCH 23390: evidence against the autoreceptor hypothesis

M Morelli, R Longoni, L Spina, G Di Chiara

Antagonism of apomorphine-induced yawning by SCH 23390: evidence against the autoreceptor hypothesis

M Morelli et al. Psychopharmacology (Berl). 1986.

Abstract

The ability of apomorphine to induce yawning (YWG) in normal and reserpinized rats and its interaction with SCH 23390, a potent and specific D-1 receptor antagonist, was studied. Apomorphine was more potent in inducing YWG in reserpine-pretreated as compared to control rats. SCH 23390, in low doses (0.05 mg/kg SC), was able to significantly reduce the YWG evoked by apomorphine both in control and in reserpine-pretreated rats. The results indicate that D-1 receptors contribute to YWG elicited by apomorphine and contradict the idea that this effect is mediated by DA autoreceptors.

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