The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
- PMID: 30887376
- PMCID: PMC6447695
- DOI: 10.1007/s10654-019-00502-9
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Abstract
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
Keywords: Childhood traits and disorders; Consortium; Genetics; Longitudinal.
Figures


References
-
- Global Burden of Disease Pediatrics Collaboration Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013: findings from the global burden of disease 2013 study. JAMA Pediatr. 2016;170:267–287. doi: 10.1001/jamapediatrics.2015.4276. - DOI - PMC - PubMed
MeSH terms
Grants and funding
- R01 MH063706/MH/NIMH NIH HHS/United States
- RC2 MH089995/MH/NIMH NIH HHS/United States
- TPR 15-230/HX/HSRD VA/United States
- MC_UP_A620_1014/MRC_/Medical Research Council/United Kingdom
- R01 HD056465/HD/NICHD NIH HHS/United States
- K05 AA000145/AA/NIAAA NIH HHS/United States
- R01 ES023262/ES/NIEHS NIH HHS/United States
- MC_UU_12011/1/MRC_/Medical Research Council/United Kingdom
- UG3 OD023286/OD/NIH HHS/United States
- G0400491/MRC_/Medical Research Council/United Kingdom
- RC2 MH089951/MH/NIMH NIH HHS/United States
- K99 ES027870/ES/NIEHS NIH HHS/United States
- P50 HD028138/HD/NICHD NIH HHS/United States
- R01 ES021801/ES/NIEHS NIH HHS/United States
- P30 ES007048/ES/NIEHS NIH HHS/United States
- U01 HG004438/HG/NHGRI NIH HHS/United States
- R01 MH081802/MH/NIMH NIH HHS/United States
- U01 HG004446/HG/NHGRI NIH HHS/United States
- R01 ES016535/ES/NIEHS NIH HHS/United States
- MC_U147585827/MRC_/Medical Research Council/United Kingdom
- R01 HL076647/HL/NHLBI NIH HHS/United States
- 19169/CRUK_/Cancer Research UK/United Kingdom
- R01 AI102960/AI/NIAID NIH HHS/United States
- R01 HL087679/HL/NHLBI NIH HHS/United States
- R01 CA094143/CA/NCI NIH HHS/United States
- P01 ES009581/ES/NIEHS NIH HHS/United States
- P01 ES022845/ES/NIEHS NIH HHS/United States
- R01 HL061768/HL/NHLBI NIH HHS/United States
- R01 HD042157/HD/NICHD NIH HHS/United States
- P50 CA180905/CA/NCI NIH HHS/United States
- MC_U147585819/MRC_/Medical Research Council/United Kingdom
- MR/K002449/1/MRC_/Medical Research Council/United Kingdom
- MC_UU_00011/1/MRC_/Medical Research Council/United Kingdom
- U01 LM012675/LM/NLM NIH HHS/United States
- U01 NS047537/NS/NINDS NIH HHS/United States
- R01 AG046938/AG/NIA NIH HHS/United States
- R01 AA009203/AA/NIAAA NIH HHS/United States
- MR/L01341X/1/MRC_/Medical Research Council/United Kingdom
- G0601361/MRC_/Medical Research Council/United Kingdom
- G0901245/MRC_/Medical Research Council/United Kingdom
- 104150/WT_/Wellcome Trust/United Kingdom
- 27307C0010/ES/NIEHS NIH HHS/United States
- U01 DK062418/DK/NIDDK NIH HHS/United States
- RC2 HL101651/HL/NHLBI NIH HHS/United States
- EP-C-15-001/EPA/EPA/United States
- P01 ES011627/ES/NIEHS NIH HHS/United States
- MC_PC_15018/MRC_/Medical Research Council/United Kingdom
- MC_UU_12013/1/MRC_/Medical Research Council/United Kingdom
- R01 HL087680/HL/NHLBI NIH HHS/United States
- MC_UU_00011/6/MRC_/Medical Research Council/United Kingdom
- MR/M021475/1/MRC_/Medical Research Council/United Kingdom
- MC_UU_12013/4/MRC_/Medical Research Council/United Kingdom
- U24 MH068457/MH/NIMH NIH HHS/United States
- R01 AA012502/AA/NIAAA NIH HHS/United States
- R03 ES014046/ES/NIEHS NIH HHS/United States
- RL1 MH083268/MH/NIMH NIH HHS/United States
- U01 HG004423/HG/NHGRI NIH HHS/United States
- MC_UU_12013/5/MRC_/Medical Research Council/United Kingdom
- N01 ES075558/ES/NIEHS NIH HHS/United States
- MC_U147585824/MRC_/Medical Research Council/United Kingdom
- R01 HD034568/HD/NICHD NIH HHS/United States
- G9815508/MRC_/Medical Research Council/United Kingdom
- R37 AA012502/AA/NIAAA NIH HHS/United States
LinkOut - more resources
Full Text Sources
Research Materials