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. 2019 Mar 19;14(3):e0213202.
doi: 10.1371/journal.pone.0213202. eCollection 2019.

Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls

Guido J Bakker  1 , Manon C Vanbellinghen  1 , Torsten P Scheithauer  2   3 , C Bruce Verchere  4 , Erik S Stroes  1 , Nyanza K L M Timmers  1 , Hilde Herrema  2 , Max Nieuwdorp  1   2   3   5   6 , Hein J Verberne  7 , Daniël H van Raalte  3
Affiliations

Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls

Guido J Bakker et al. PLoS One. .

Abstract

Introduction: Increasing evidence indicates that the development of type 2 diabetes is driven by chronic low grade beta-cell inflammation. However, it is unclear whether pancreatic inflammation can be noninvasively visualized in type 2 diabetes patients. We aimed to assess pancreatic 18F-FDG uptake in type 2 diabetes patients and controls using 18F-fluorodeoxylglucose positron emission tomography/computed tomography (18F-FDG PET/CT).

Material and methods: In this retrospective cross-sectional study, we enrolled 20 type 2 diabetes patients and 65 controls who had undergone a diagnostic 18F-FDG PET/CT scan and obtained standardized uptake values (SUVs) of pancreas and muscle. Pancreatic SUV was adjusted for background uptake in muscle and for fasting blood glucose concentrations.

Results: The maximum pancreatic SUVs adjusted for background muscle uptake (SUVmax.m) and fasting blood glucose concentration (SUVglucose) were significantly higher in diabetes patients compared to controls (median 2.86 [IQR 2.24-4.36] compared to 2.15 [IQR 1.51-2.83], p = 0.006 and median 2.76 [IQR 1.18-4.34] compared to 1.91 [IQR 1.27-2.55], p<0.001, respectively). In linear regression adjusting for age and body mass index, diabetes remained the main predictor of SUVmax.m and SUVglucose.

Conclusion: Pancreatic 18F-FDG uptake adjusted for background muscle uptake and fasting blood glucose concentration was significantly increased in type 2 diabetes patients.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Pancreatic glucose uptake.
Maximum pancreatic SUV corrected for background muscle uptake (a) and for fasting blood glucose (b). Shown are median values with IQR. **, p<0.01; ***, p<0.001.
See this image and copyright information in PMC

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