Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jun;16(6):768-771.
doi: 10.1513/AnnalsATS.201812-844RL.

Higher Plasma Endothelial Markers in Adults with Cystic Fibrosis Compared with Healthy Age-matched Control Subjects

Pavan K Bhatraju  1 , Katie B Hisert  1 , Moira L Aitken  1 , Christopher H Goss  1 , W Conrad Liles  1 , William A Altemeier  1
Affiliations

Higher Plasma Endothelial Markers in Adults with Cystic Fibrosis Compared with Healthy Age-matched Control Subjects

Pavan K Bhatraju et al. Ann Am Thorac Soc. 2019 Jun.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Plasma angiopoietin 1 (Ang-1) and Ang-1/Ang-2 concentrations are higher in adults with cystic fibrosis (CF) than in healthy adults. Plasma was collected in adults with CF (n = 20) during times of relative wellness and in age-, sex- and ethnicity-matched control subjects (n = 20). Five plasma markers of endothelial function were measured: Ang-1, Ang-2, soluble vascular cell adhesion molecule-1 (sVCAM-1), von Willebrand factor (vWF), and soluble intercellular adhesion molecule-1 (sICAM-1). For each biomarker, comparisons were made with a Mann-Whitney test. Significance was based on a P < 0.01 based on Bonferroni correction for multiple hypotheses. Horizontal lines depict the median values and first and third quartile results for the distribution of plasma biomarkers between healthy adults and adults with CF. ***P < 0.001.
See this image and copyright information in PMC

References

    1. Fahy JV, Keoghan MT, Crummy EJ, FitzGerald MX. Bacteraemia and fungaemia in adults with cystic fibrosis. J Infect. 1991;22:241–245. - PubMed
    1. Cargill J, Etherington C, Peckham D, Conway S, Denton M. Bloodstream infections in cystic fibrosis: nine years of experience in both adults and children. J Cyst Fibros. 2012;11:337–339. - PubMed
    1. Campbell SG, Marrie TJ, Anstey R, Dickinson G, Ackroyd-Stolarz S. The contribution of blood cultures to the clinical management of adult patients admitted to the hospital with community-acquired pneumonia: a prospective observational study. Chest. 2003;123:1142–1150. - PubMed
    1. Falguera M, Trujillano J, Caro S, Menéndez R, Carratalà J, Ruiz-González A, et al. NAC-CALIDAD (Proyecto Integrado de Investigación de la Sociedad Española de Patología del Aparato Respiratorio sobre Infecciones Respiratorias de Vías Bajas) Study Group. A prediction rule for estimating the risk of bacteremia in patients with community-acquired pneumonia. Clin Infect Dis. 2009;49:409–416. - PubMed
    1. Tang AC, Turvey SE, Alves MP, Regamey N, Tümmler B, Hartl D. Current concepts: host-pathogen interactions in cystic fibrosis airways disease. Eur Respir Rev. 2014;23:320–332. - PMC - PubMed

Publication types