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Comment
. 2019 Mar 18;35(3):337-339.
doi: 10.1016/j.ccell.2019.02.013.

No Matter How You Splice It, RBM39 Inhibition Targets Spliceosome Mutant AML

Rozario Thomas  1 , Ravindra Majeti  2
Affiliations
Comment

No Matter How You Splice It, RBM39 Inhibition Targets Spliceosome Mutant AML

Rozario Thomas et al. Cancer Cell. .

Abstract

A report in this issue of Cancer Cell identifies the RNA-binding protein RBM39 as a potential target in spliceosome mutant AML that can be targeted by existing sulfonamide drugs. These results support a proposed clinical trial in patients with myeloid malignancies bearing spliceosome mutations relapsed or refractory to standard therapy.

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  • Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia.
    Wang E, Lu SX, Pastore A, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, Uehara T, Owa T, Tibes R, Krainer AR, Abdel-Wahab O, Aifantis I. Wang E, et al. Cancer Cell. 2019 Mar 18;35(3):369-384.e7. doi: 10.1016/j.ccell.2019.01.010. Epub 2019 Feb 21. Cancer Cell. 2019. PMID: 30799057 Free PMC article.

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