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Comment
. 2019 Mar 18;29(6):R220-R223.
doi: 10.1016/j.cub.2019.01.055.

Immunology: Skin T Cells Switch Identity to Protect and Heal

Silvia Ariotti  1 , Marc Veldhoen  2
Affiliations
Free article
Comment

Immunology: Skin T Cells Switch Identity to Protect and Heal

Silvia Ariotti et al. Curr Biol. .
Free article

Abstract

Skin-resident T cells protect against invasive microorganisms. A new study reports that commensal-specific type-17 (but not type-1) T cells in the skin are poised to switch to a type-2 response upon tissue injury and contribute to wound repair.

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  • Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.
    Harrison OJ, Linehan JL, Shih HY, Bouladoux N, Han SJ, Smelkinson M, Sen SK, Byrd AL, Enamorado M, Yao C, Tamoutounour S, Van Laethem F, Hurabielle C, Collins N, Paun A, Salcedo R, O'Shea JJ, Belkaid Y. Harrison OJ, et al. Science. 2019 Jan 4;363(6422):eaat6280. doi: 10.1126/science.aat6280. Epub 2018 Dec 6. Science. 2019. PMID: 30523076 Free PMC article.

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