Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 18;7(3):47.
doi: 10.3390/medsci7030047.

Neurorehabilitation of Traumatic Brain Injury (TBI): A Clinical Review

Affiliations
Review

Neurorehabilitation of Traumatic Brain Injury (TBI): A Clinical Review

Michael Oberholzer et al. Med Sci (Basel). .

Abstract

Traumatic brain injury (TBI) and its potential long-term consequences are of major concern for public health. Neurorehabilitation of affected individuals has some specific characteristics in contrast to neurorehabilitation of patients with acquired brain lesions of other aetiology. This review will deal with the clinical consequences of the distinct lesions of TBI. In severe TBI, clinical course often follows a typical initial sequence of coma; followed by disturbed consciousness; later, post-traumatic agitation and amnesia; and finally, recovery of function occurs. In the different phases of neurorehabilitation, physicians should be aware of typical medical complications such as paroxysmal sympathetic hyperactivity, posttraumatic hydrocephalus, and posttraumatic neuroendocrine dysfunctions. Furthermore, we address questions on timing and on existing evidence for different rehabilitation programmes and for holistic neuropsychological rehabilitation approaches.

Keywords: cognitive rehabilitation; disorders of consciousness; neuropsychological rehabilitation; neurorehabilitation; paroxysmal sympathetic hyperactivity; posttraumatic agitation; posttraumatic hydrocephalus; posttraumatic neuroendocrine disorders; traumatic brain injury.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Thurman D.J., Alverson C., Dunn K.A., Guerrero J., Sniezek J.E. Traumatic brain injury in the United States: A public health perspective. J. Head Trauma Rehabil. 1999;14:602–615. doi: 10.1097/00001199-199912000-00009. - DOI - PubMed
    1. Zaloshnja E., Miller T., Langlois J.A., Selassie A.W. Prevalence of long-term disability from traumatic brain injury in the civilian population of the United States, 2005. J. Head Trauma Rehabil. 2008;23:394–400. doi: 10.1097/01.HTR.0000341435.52004.ac. - DOI - PubMed
    1. Walder B., Haller G., Rebetez M.M.L., Delhumeau C., Bottequin E., Schoettker P., Ravussin P., Brodmann Maeder M., Stover J.F., Zürcher M., et al. Severe traumatic brain injury in a high-income country: An epidemiological study. J. Neurotrauma. 2013;30:1934–1942. doi: 10.1089/neu.2013.2955. - DOI - PubMed
    1. Leo P., McCrea M. Epidemiology. In: Laskowitz D., Grant G., editors. Translational Research in Traumatic Brain Injury. CRC Press/Taylor and Francis Group; Boca Raton, FL, USA: 2016. Frontiers in Neuroscience.
    1. Adams J.H., Doyle D., Ford I., Gennarelli T.A., Graham D.I., Mclellan D.R. Diffuse axonal injury in head injury: Definition, diagnosis and grading. Histopathology. 1989;15:49–59. doi: 10.1111/j.1365-2559.1989.tb03040.x. - DOI - PubMed