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Case Reports
. 2019 Aug;94(4):407-409.
doi: 10.1016/j.diagmicrobio.2019.02.014. Epub 2019 Feb 21.

Emergence of colistin resistance during treatment of recurrent pneumonia caused by carbapenemase producing Klebsiella pneumoniae

Veerle Matheeussen  1 , Basil Britto Xavier  2 , Ingrid Mermans  3 , Annick De Weerdt  4 , Christine Lammens  2 , Herman Goossens  5 , Hilde Jansens  3 , Surbhi Malhotra-Kumar  2
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Case Reports

Emergence of colistin resistance during treatment of recurrent pneumonia caused by carbapenemase producing Klebsiella pneumoniae

Veerle Matheeussen et al. Diagn Microbiol Infect Dis. 2019 Aug.

Abstract

A 60-year-old woman received meropenem/colistin treatment for bilateral pneumonia caused by a ST15 carbapenemase producing Klebsiella pneumoniae. The patient recovered but re-infection with the same (ST15), but now colistin-resistant K. pneumoniae, occurred. The molecular mechanism of the emerged colistin resistance was identified as mgrB gene modification by insertion element (IS) IS903B.

Keywords: Carbapenemase producing Enterobactericeae; Colistin resistance; K. pneumoniae; ST15.

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