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Case Reports
. 2019 Jul;104(7):e326-e329.
doi: 10.3324/haematol.2018.214981. Epub 2019 Mar 19.

Branched clonal evolution: nodal follicular lymphoma and primary diffuse large B-cell lymphoma of the central nervous system

Gilberto I Barranco  1   2 , Sara Fernández  3 , Raquel Oña  4 , Julia González-Rincón  5 , Angel Martínez-Ramírez  6 , Ana Teijo  1 , Francisca I Camacho  7 , Fernando J Pinedo  8 , Margarita Sánchez-Beato  5 , Lucia Pedrosa  5 , Adolfo de la Fuente  4 , Mónica Estévez  4 , Rebeca Iglesias  4 , Carlos Montalbán  4 , Juan F García  9   3
Affiliations
Case Reports

Branched clonal evolution: nodal follicular lymphoma and primary diffuse large B-cell lymphoma of the central nervous system

Gilberto I Barranco et al. Haematologica. 2019 Jul.
No abstract available

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Figures

Figure 1.
Figure 1.
Radiological and pathological characteristics of the patient’s tumors. (A) Magnetic resonance imaging scan of the brain at diagnosis (2008) and after therapy. (B) Brain biopsy showing extensive infiltration of the parenchyma by primary central nervous system lymphoma. (C) Lymph node biopsy (1998), showing distinctive features of follicular lymphoma. Insets show cytological details.
Figure 2.
Figure 2.
IGH clonality analysis of the patient’s tumors. (A) Monoclonal Vн-FR2-Jн rearrangements and Vн3 usage. (B) Sanger sequencing of the rearranged regions showing hypermutated IGHV 3-53 sequences and ongoing mutations in both lymphomas: FL (91.9 % homology with the germline) and PCNSL (82.2% homology). Asterisks indicate identity with germline. FL: follicular lymphoma; PCNSL: primary central nervous system lymphoma.
Figure 3.
Figure 3.
Mutational analysis of the tumors. (A) Summary of variants detected by next-generation sequencing in the two tumors. (B) Mutational relationship and branched pattern. FL: follicular lymphoma; PCNSL: primary central nervous system lymphoma.
See this image and copyright information in PMC

References

    1. Schürch CM, Federmann B, Quintanilla-Martinez L, Fend F. Tumor heterogeneity in lymphomas: a different breed. Pathobiology. 2018;85(1-2):130–145. - PubMed
    1. Jiang Y, Redmond D, Nie K, et al. Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas. Genome Biol. 2014;15(8):432. - PMC - PubMed
    1. Green MR, Gentles AJ, Nair RV, et al. Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Blood. 2013;121(9):1604–1611. - PMC - PubMed
    1. Landau DA, Carter SL, Getz G, Wu CJ. Clonal evolution in hematologic malignancies and therapeutic implications. Leukemia. 2014; 28(1):34–43. - PMC - PubMed
    1. Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375–2390. - PMC - PubMed

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