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Comment
. 2019 Apr 2;116(14):6525-6527.
doi: 10.1073/pnas.1902734116. Epub 2019 Mar 19.

Pseudomonas aeruginosa in cystic fibrosis: A chronic cheater

Christopher M Waters  1 , Joanna B Goldberg  2
Affiliations
Comment

Pseudomonas aeruginosa in cystic fibrosis: A chronic cheater

Christopher M Waters et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Speculative and simplified model of P. aeruginosa evolution in the CF lung (no. 1). The CF lung is initially colonized by P. aeruginosa that has wild-type (WT) Las, Rhl, and PQS QS systems, leading to high concentrations of all AIs (no. 2). Over time, LasR− strains evolve, possibly due to the selection for cheats that utilize the public good of the WT strain. As the LasR− cells increase in frequency, concentrations of AIs decrease (no. 3). LasR− cheats can regain functionality of the Rhl QS system by mutation of mexT. The LasR− and MexT− strains are able to produce proteases, C4-HSL, and PQS, but not N-3OC12-HSL (no. 4). The Rhl-activated strains can themselves be cheated on by null mutations to the PQS system. All of these strain phenotypes have been observed in clinical isolates, although the mutations underpinning them are not always understood. We also expect that each of these morphotypes can coexist in an infected lung due to spatial heterogeneity. RhlR− strains do not emerge as cheats because they have a fitness defect when growing in the presence of the reprogrammed LasR mutants with functioning Rhl systems. This also represents one evolutionary pathway, and we expect that there are other targets of selection that can lead to similar P. aeruginosa morphotypes.
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References

    1. Kostylev M, et al. Evolution of the Pseudomonas aeruginosa quorum-sensing hierarchy. Proc Natl Acad Sci USA. 2019;116:7027–7032. - PMC - PubMed
    1. Chen R, Déziel E, Groleau M-C, Schaefer AL, Greenberg EP. Social cheating in a Pseudomonas aeruginosa quorum-sensing variant. Proc Natl Acad Sci USA. 2019;116:7021–7026. - PMC - PubMed
    1. Passador L, Cook JM, Gambello MJ, Rust L, Iglewski BH. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science. 1993;260:1127–1130. - PubMed
    1. Pearson JP, et al. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci USA. 1994;91:197–201. - PMC - PubMed
    1. Ochsner UA, Reiser J. Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proc Natl Acad Sci USA. 1995;92:6424–6428. - PMC - PubMed

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