In vivo ways to unveil off-targets
- PMID: 30890764
- PMCID: PMC6796904
- DOI: 10.1038/s41422-019-0159-2
In vivo ways to unveil off-targets
Comment on
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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.Science. 2019 Apr 19;364(6437):289-292. doi: 10.1126/science.aav9973. Epub 2019 Feb 28. Science. 2019. PMID: 30819928 Free PMC article.
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Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice.Science. 2019 Apr 19;364(6437):292-295. doi: 10.1126/science.aaw7166. Epub 2019 Feb 28. Science. 2019. PMID: 30819931
References
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- Zuo E., et al. Science10.1126/science.aav9973 (2019). - PubMed
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