Switching APOBEC mutation signatures

doi:10.1038/s41576-019-0116-4

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. 2019 May;20(5):253.

doi: 10.1038/s41576-019-0116-4.

Switching APOBEC mutation signatures

Darren J Burgess¹

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PMID: 30890789
DOI: 10.1038/s41576-019-0116-4

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Switching APOBEC mutation signatures

Darren J Burgess. Nat Rev Genet. 2019 May.

. 2019 May;20(5):253.

doi: 10.1038/s41576-019-0116-4.

Author

Darren J Burgess¹

Affiliation

¹ Nature Reviews Genetics, . nrg@nature.com.

PMID: 30890789
DOI: 10.1038/s41576-019-0116-4

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APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.
Roper N, Gao S, Maity TK, Banday AR, Zhang X, Venugopalan A, Cultraro CM, Patidar R, Sindiri S, Brown AL, Goncearenco A, Panchenko AR, Biswas R, Thomas A, Rajan A, Carter CA, Kleiner DE, Hewitt SM, Khan J, Prokunina-Olsson L, Guha U. Roper N, et al. Cell Rep. 2019 Mar 5;26(10):2651-2666.e6. doi: 10.1016/j.celrep.2019.02.028. Cell Rep. 2019. PMID: 30840888 Free PMC article.
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.
Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC, Grossmann S, Dawson KJ, Ju YS, Iorio F, Tubio JMC, Koh CC, Georgakopoulos-Soares I, Rodríguez-Martín B, Otlu B, O'Meara S, Butler AP, Menzies A, Bhosle SG, Raine K, Jones DR, Teague JW, Beal K, Latimer C, O'Neill L, Zamora J, Anderson E, Patel N, Maddison M, Ng BL, Graham J, Garnett MJ, McDermott U, Nik-Zainal S, Campbell PJ, Stratton MR. Petljak M, et al. Cell. 2019 Mar 7;176(6):1282-1294.e20. doi: 10.1016/j.cell.2019.02.012. Cell. 2019. PMID: 30849372 Free PMC article.

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APOBEC affects tumor evolution and age at onset of lung cancer in smokers.
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APOBEC shapes tumor evolution and age at onset of lung cancer in smokers.
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References

Original articles

1. Petljak, M. et al. Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis. Cell 176, 1282–1294.e20 (2019) - DOI
1. Roper, N. et al. APOBEC mutagenesis and copy-number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors. Cell Rep 26, 2651–2666.e6 (2019) - DOI

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[1] Petljak, M. et al. Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis. Cell 176, 1282–1294.e20 (2019) - DOI

[2] Petljak, M. et al. Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis. Cell 176, 1282–1294.e20 (2019) - DOI

[3] Roper, N. et al. APOBEC mutagenesis and copy-number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors. Cell Rep 26, 2651–2666.e6 (2019) - DOI

[4] Roper, N. et al. APOBEC mutagenesis and copy-number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors. Cell Rep 26, 2651–2666.e6 (2019) - DOI

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Switching APOBEC mutation signatures

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