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Review
. 2019 Mar 5:10:387.
doi: 10.3389/fimmu.2019.00387. eCollection 2019.

Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches

Daniel Lucas  1   2
Affiliations
Review

Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches

Daniel Lucas. Front Immunol. .

Abstract

Hematopoietic stem cells (HSC) are the most powerful type of adult stem cell found in the body. Hematopoietic stem cells are multipotent and capable of giving rise to all other types of hematopoietic cells found in the organism. A single HSC is capable of regenerating a functional hematopoietic system when transplanted into a recipient. Hematopoietic stem cells reside in the bone marrow in specific multicellular structures called niches. These niches are indispensable for maintaining and regulating HSC numbers and function. It has become increasingly clearer that HSC and their niches can also be regulated by migrating leukocytes. Here we will discuss the composition of murine bone marrow niches and how HSC and their niches are regulated by different types of leukocytes that traffic between the periphery and the niche. Unless otherwise indicated all the studies discussed below were performed in mouse models.

Keywords: Tregs; hematopoietic stem cell; leukocyte trafficking; neutrophils; niches.

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Figures

Figure 1
Figure 1
Scheme showing key components of murine BM HSC niches. Blue arrows indicate regulation. HSC, hematopoietic stem cells; HSPC, hematopoietic stem and progenitor cells.
Figure 2
Figure 2
Scheme showing how leukocyte trafficking regulates (and is regulated by) niche cells. Dashed lines indicate differentiation. Solid black arrows indicate migration. Solid green arrows indicate regulation by CXCL12. Solid orange arrows indicate regulation by macrophages. HSC, hematopoietic stem cells; ETP, early T cell progenitor; G-CSF, granulocyte colony-stimulating factor.
See this image and copyright information in PMC

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References

    1. Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, et al. . Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. (2013) 502:637–43. 10.1038/nature12612 - DOI - PMC - PubMed
    1. Ding L, Morrison SJ. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. (2013) 495:231–5. 10.1038/nature11885 - DOI - PMC - PubMed
    1. Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. (2012) 481:457–62. 10.1038/nature10783 - DOI - PMC - PubMed
    1. Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, et al. . CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. (2013) 495:227–30. 10.1038/nature11926 - DOI - PMC - PubMed
    1. Poulos MG, Guo P, Kofler NM, Pinho S, Gutkin MC, Tikhonova A, et al. . Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep. (2013) 4:1022–34. 10.1016/j.celrep.2013.07.048 - DOI - PMC - PubMed

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