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Review
. 2019 Jan 23;4(1):30-35.
doi: 10.1016/j.ncrna.2019.01.002. eCollection 2019 Mar.

miR-223 and other miRNA's evaluation in chronic kidney disease: Innovative biomarkers and therapeutic tools

Valérie Metzinger-Le Meuth  1 , Laurent Metzinger  2
Affiliations
Review

miR-223 and other miRNA's evaluation in chronic kidney disease: Innovative biomarkers and therapeutic tools

Valérie Metzinger-Le Meuth et al. Noncoding RNA Res. .

Erratum in

Abstract

microRNAs (miRNAs) represent a recent breakthrough regarding gene expression regulation. They are instrumental players known to regulate post-transcriptional expression. miRNAs are short single stranded RNAs that base-pair with target mRNAs in specific regions mainly within their 3' untranslated region. We know now that miRNAs are involved in kidney physiopathology. We outline in this review the recent discoveries made on the roles of miRNAs in cellular and animal models of kidney disease but also in patients suffering from chronic kidney disease, acute kidney injury and so forth. miRNAs are potential innovative biomarkers in nephrology, but before being used in daily clinical routine, their expression in large cohorts will have to be assessed, and an effort will have to be made to standardize measurement methods and to select the most suitable tissues and biofluids. In addition to a putative role as biomarkers, up- or down-regulating miRNAs is a novel therapeutic approach to cure kidney disorders. We discuss in this review recent methods that could be used to deliver miRNAs in a specific and suitable way in kidney and other organs damaged by kidney failure such as the cardiovascular system.

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Figures

Fig. 1
Fig. 1
The potential of miRNAs to assess and cure renal disorders: Preclinical models are useful to screen miRNAs implicated in nephrological diseases. miRNAs can also be used as innovative therapeutic approaches to improve kidney pathology.
Fig. 2
Fig. 2
Altering a miRNA expression to counteract pathologies in ageing and diabetic patients, prone to develop CKD. The expression levels of a panel of adapted miRNAs can be altered according to the clinical context. Various approaches are at the moment developed for this purpose. Second generation gene therapy vectors, such as lentiviruses can be used, to produce RNA constructs in situ. Gold or iron-nanoparticles can also be used to deliver RNAs. Finally, the RNAs can be chemically modified to increase their stability. LNA: locked nucleic acid, MOE: 2′—O-(2-Methoxyethyl)- oligoribonucleotide.
See this image and copyright information in PMC

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